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تعداد نتایج: 73 فیلتر نتایج به سال:
Single-Ig-interleukin-1 related receptor (SIGIRR) is a member of the interleukin (IL)1/Toll-like receptor (TLR) family. It negatively regulates inflammation, rendering SIGIRR /mice more susceptible to inflammatory challenge. This susceptibility extends to the brain, where increased responsiveness to lipopolysaccharide (LPS) has been observed in SIGIRRdeficient mice. While this is likely due to ...
Endothelial dysfunction and activation occur in the vasculature and are believed to contribute to the pathogenesis of cardiovascular diseases. We have shown that 20-hydroxy5,8,11,14-eicosatetraenoic acid (20-HETE), a cytochrome P450 4A-derived eicosanoid that promotes vasoconstriction in the microcirculation, uncouples endothelial nitric-oxide synthase (eNOS) and reduces nitric oxide (NO) level...
Background: We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A 2 (TP) receptors was studied. Methods and Results: After organ culture of the arteries, VSMC TP receptors were studied by using myography, real-time PCR and imm...
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