Let be a sequence of weakly negative dependent (denoted by, WND) random variables with common distribution function F and let be other sequence of positive random variables independent of and for some and for all . In this paper, we study the asymptotic behavior of the tail probabilities of the maximum, weighted sums, randomly weighted sums and randomly indexed weighted sums of heavy...

Booleanization of frames or uniform frames, which is not functorial under the basic choice of morphisms, becomes functorial in the categories with weakly open homomorphisms or weakly open uniform homomorphisms. Then, the construction becomes a reflection. In the uniform case, moreover, it also has a left adjoint. In connection with this, certain dual equivalences concerning uniform spaces and u...

Purpose: Immunohistochemistry (lHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the traditional ligand-binding assay (LBA). The purpose of this study was to evaluate the ability of ER status determination by IHC, compared with LBA, to predict clinical outcomeespecially response to...

Booleanization of frames or uniform frames, which is not functorial under the basic choice of morphisms, becomes functorial in the categories with weakly open homomorphisms or weakly open uniform homomorphisms. Then, the construction becomes a reflection. In the uniform case, moreover, it also has a left adjoint. In connection with this, certain dual equivalences concerning uniform spaces and u...

BACKGROUND Endocrine-disrupting chemicals (EDCs) influence the activity of estrogen receptors (ERs) and alter the function of the endocrine system. However, the diversity of EDC effects and mechanisms of action are poorly understood. OBJECTIVES We examined the agonistic activity of EDCs through ERα and ERβ. We also investigated the effects of EDCs on ER-mediated target genes. METHODS HepG2 ...

Estrogenic industrial compounds such as bisphenol A (BPA) and nonylphenol typically bind estrogen receptor (ER) alpha and ERBeta and induce transactivation of estrogen-responsive genes/reporter genes, but their potencies are usually greater than or equal to 1,000-fold lower than observed for 17Beta-estradiol. Risk assessment of estrogenic compounds on the basis of their potencies in simple repo...

Intracisternal granules (ICG) develop in the rough ER of hyperstimulated thyrotrophs or thyroid hormone-secreting cells of the anterior pituitary gland. To determine the fate of these granules, we carried out morphological and immunocytochemical studies on pituitaries of thyroxine-treated, thyroidectomized rats. Under these conditions the ER of thyrotrophs is dramatically dilated and contains a...