Abstract BACKGROUND The assessment of BM response to WBRT and its impact on NCF in clinical trials has been limited by lack standardized imaging protocols. NRG-CC001 is a randomized trial requiring pre-specified MRI protocols at baseline 6-months, providing uniform dataset investigate if RR correlates with changes. METHODS patients hippocampal avoidance (HA-WBRT) or WBRT. was analyzed using 6-m...

Introduction: Recent advances to preserve neurocognitive function in patients treated for brain metastases include stereotactic radiosurgery (SRS), hippocampal avoidance whole radiation therapy (HA-WBRT), and memantine administration. The hippocampus, corpus callosum, fornix, amygdala are key substructures with a low propensity metastases. Herein, we report our preliminary experience using “mem...

BACKGROUND Limited data guide radiotherapy choices for patients with brain metastases. This survey aimed to identify patient, physician, and practice setting variables associated with reported preferences for different treatment techniques. METHOD 277 members of the American Society for Radiation Oncology (6% of surveyed physicians) completed a survey regarding treatment preferences for 21 hy...

BACKGROUND The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, by (1)H-MR spectroscopy focused on the hippocampus. METHODS Patients with brain metastases underwent whole...

PURPOSE To determine the incidence of brain atrophy and dementia after whole-brain radiotherapy (WBRT) in patients with brain metastases not undergoing surgery. METHODS AND MATERIALS Eligible patients underwent WBRT to 40 Gy in 20 fractions with or without a 10-Gy boost. Brain magnetic resonance imaging or computed tomography and Mini-Mental State Examination (MMSE) were performed before and ...

This report is to be commended for evaluating local control and overall survival outcomes for metastases in eloquent areas. It is a valuable addition to the literature. What is interesting is that all patients were treated up front with whole brain radiation (WBRT) and stereotactic radiosurgery (SRS) versus SRS alone. The question is: Why was WBRT given? The rate of distant brain relapse was no...

BACKGROUND For patients with a brain metastasis (BM), systemic therapy is usually administered after the completion of radiotherapy, especially in cases of multiple BMs. However, the role of systemic therapy in patients with a limited number of BMs is not clear. Therefore, we conducted a retrospective study to explore this question. METHODS Consecutive patients with a pathologically confirmed...

PURPOSE In this retrospective study, we compared the incidence of leptomeningeal carcinomatosis or dural metastasis (LMCDM) in patients who received whole brain radiotherapy (WBRT), partial radiotherapy (PRT), or no radiotherapy (RT) following resection of brain metastases from breast cancer. MATERIALS AND METHODS Fifty-one patients with breast cancer underwent surgical resection for newly di...

In a plenary session at ASCO 2015, Brown et al. presented the results of Alliance NCCTG N0574, a phase 3 trial comparing whole-brain radiation therapy (WBRT) plus radiosurgery (SRS) to SRS alone in patients with 1 to 3 brain metastases, each <3 cm, by contrast magnetic resonance imaging (MRI). The primary endpoint was cognitive progression (CP), defined as decline >1 standard deviation (SD) fro...