The most common adverse effects that are related to all-trans retinoic acid (atRA) treatment are irritation and dryness of the skin. atRA therapy is reported to impair barrier function as achieved by trans-epidermal water loss (TEWL). Treatment with nicotinamide prior to initiation of atRA therapy provides additional barrier protection and thus reduces susceptibility of retinoic acid. Our previ...

Despite the obvious importance of roots to agro-ecosystem functioning, few studies have attempted to examine the effects of warming on root biomass and distribution, especially under different tillage systems. In this study, we performed a field warming experiment using infrared heaters on winter wheat, in long-term conventional tillage and no-tillage plots, to determine the responses of root b...

PURPOSE To evaluate the levels of dinucleotides diadenosine tetraphosphate (Ap(4)A) and diadenosine pentaphosphate (Ap(5)A) in tears of patients wearing rigid gas permeable (RGP) contact lenses on a daily wear basis and of patients wearing reverse-geometry RGP lenses overnight for orthokeratology treatment. METHODS Twenty-two young volunteers (10 females, 12 males; 23.47 ± 4.49 years) were fi...

OBJECTIVE The objective of this review was to systematically analyze the trials on the effectiveness of perioperative warming in surgical patients. METHODS A systematic review of the literature was undertaken. Clinical trials on perioperative warming were selected according to specific criteria and analyzed to generate summative data expressed as standardized mean difference (SMD). RESULTS ...

comparing the preventive effect of adhesive tape and eye ointment on eye dryness and corneal abrasion in icu patients     sharifi tabar z [1] , shaeri m [2] , nazari r [3] , adib hajbagari m [4] , masoudi alvi n [5]     received: 29 feb , 2012 accepted: 04 jun , 2012     abstract   background & aims : eye complications are common in intensive care units’ patients. different methods are recommen...

Between 4 and 6 of every 10 women undergoing menopause suffer from symptoms related to vaginal atrophy. Dyspareunia, in relation to vaginal dryness, can lead to sexual dysfunction. Vaginal hormone treatment has been regarded as the ideal treatment for vaginal atrophy management. Laser treatment is used to reduce the symptoms generated by vaginal atrophy, and to offer patients an alternative to ...

BACKGROUND The most common adverse effects of CPAP are related to the upper airways. We evaluated upper-airway symptoms before and after a CPAP trial as well as their effect on CPAP adherence. We also evaluated the effect of humidification added to CPAP therapy on upper-airway symptoms. METHODS We followed for 1 y 536 subjects with obstructive sleep apnea scheduled consecutively for CPAP init...

[1] Mineralogical, geological, geophysical, and isotopic data recently returned from Mars suggest that the delivery of sulfur gases to the atmosphere may have played a significant role in the planet’s early evolution. Using the Gusev Crater basalt composition and a batch melting model, we obtain a high sulfur solubility, approximately 1400 ppm, in Martian mantle melts. We proceed to explore dif...

A collapse of the Atlantic Meridional Overturning Circulation (AMOC) leads to global cooling through fast feedbacks that selectively amplify the response in the Northern Hemisphere (NH). How such cooling competes with global warming has long been a topic for speculation, but was never addressed using a climate model. Here it is shown that global cooling due to a collapsing AMOC obliterates glob...

After menopause, many women experience vaginal dryness and atrophy of tissue, often attributed to the loss of estrogen. An understudied aspect of vaginal health in women who experience dryness due to atrophy is the role of the resident microbes. It is known that the microbiota has an important role in healthy vaginal homeostasis, including maintaining the pH balance and excluding pathogens. The...