Division of Cardiology, University of Washington, Seattle, WA; Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA; Cardiovascular Health Research Unit, Depts of Medicine and Epidemiology, University of Washington, Seattle, WA; Dept of Epidemiology, University of Washington, Seattle, WA; Dept of Laboratory Medicine, University of Washington, Seattle, WA; ...

The WA cross-idiotype (XId) is the major XId among human monoclonal rheumatoid factors (mRF) and is almost always associated with the light (L) chain XId, 17.109, and the heavy (H) chain XId, G6. A cell line, 35G6, was cloned that bears the WA XId, but shows no reactivity with immunoglobulin G (IgG) and is negative for the 17.109 and G6 XIds. The 35G6 L chain appears to be derived from the same...

Current dogma favors elimination of therapy-resistant cancer stem cells for chemoprevention of breast cancer. We showed recently that mammary cancer development in a transgenic mouse model (mouse mammary tumor virus-neu; MMTV-neu) was inhibited significantly upon treatment with withaferin A (WA), a steroidal lactone derived from a medicinal plant. Herein, we demonstrate that the mammary cancer ...

Vikatuni vina wajibu muhimu katika aushi ya vijana ulimwenguni. Huenda ndio sababu Karne 21 imeshuhudia ongezeko la tafiti kuhusu vikatuni. Kumekuwepo na nyingi muwala uwanja wa kiusomi. Tafiti za awali zilijikita kwenye makala, magazeti, tasnifu, vitabu Hata hivyo, hakuna utafiti vikatuni Shujaaz. Makala hii inalenga kuziba pengo hili. Utafiti huu ni kueleza namna ulivyokuzwa diskosi vya Disko...

Withaferin A (WA) is derived from the medicinal plant Withania somnifera, which has been safely used for centuries in Indian Ayurvedic medicine for treatment of different ailments. We now show, for the first time, that WA exhibits significant activity against human breast cancer cells in culture and in vivo. The WA treatment decreased viability of MCF-7 (estrogen-responsive) and MDA-MB-231 (est...

We investigated the morphology of the N1-P2 auditory evoked potential (AEP) to changes in amplitude rise time (ART) and rate of formant transition (RFT) of consonant-vowel pairs (CVs) in 4-6-year olds and adults. In the AEP session, individuals listened passively to the CVs /ba/, /wa/, and a /ba/ with a superimposed slower-rising /wa/ envelope (/ba/wa). In the behavioral session, individuals li...

Joint Center for Energy Storage Research (JCESR), PNNL, Richland, WA, USA Physical and Computational Science Directorate, PNNL, Richland, WA, USA Energy and Environmental Directorate, PNNL, Richland, WA, USA Dept.Industrial & Manufacturing Engineering, Florida State University, Tallahassee, FL, USA Department of Chemical Engineering and Materials Science, University of California, Davis, CA, US...