We investigated factors affecting the timing of signal detection by comparing variations in reporting time of known and unknown ADRs after initial drug release in the USA. Data on adverse event reactions (AERs) submitted to U.S. FDA was used. Six ADRs associated with 6 drugs (rosuvastatin, aripiprazole, teriparatide, telithromycin, exenatide, varenicline) were investigated: Changes in the propo...

In order to improve the reporting of adverse drug reactions (ADRs) as part of the routine practice at the pediatric outpatient department (OPD), we modified our ADR reporting strategy into one that facilitates the reporting process by means of a multi-disciplinary approach. In this study, we retrospectively reviewed ADR records during the period from March to September 2014 when we changed our ...

PURPOSE The improvement and linkage of two Department of Veterans Affairs (VA) databases for monitoring adverse drug reactions (ADRs) are described, with a discussion of the potential implications for improved medication safety within the VA health care system. SUMMARY Before 2007, VA had limited capability to track and evaluate ADRs across its nationwide network of health care facilities. Si...

Background: In India, spontaneous reporting of adverse drug reactions (ADRs) by healthcare professionals was initiated in 2010. The drug safety issues for geriatric population are critical due to age-related physiological changes, pharmacodynamics and pharmacokinetics changes. Objective: Our objective was to assess the spontaneous reports of adverse drug reactions, observed in geriatric patient...

PURPOSE The goal of this study was to compare the knowledge and attitudes of pharmacy and medical students regarding adverse drug reactions (ADRs), as well as their perceptions of barriers to ADR reporting, in a Higher Education Commission-recognised Pakistani university. METHODS A cross-sectional study was conducted among final-year pharmacy (n=91) and medical (n=108) students in Pakistan fr...

Oncology is one of the areas of medicine with the most active research being conducted on new drugs. New pharmacological entities frequently enter the clinical arena, and therefore, the safety profile of anticancer products deserves continuous monitoring. However, only very severe and (unusual) suspected adverse drug reactions (ADRs) are usually reported, since cancer patients develop ADRs very...

Introduction: This study aims to assess intra and interobserver reliability of transorbital ultrasound. To review the knowledge, attitude practices health care workers, including doctors, nurses, pharmacists officers in reporting adverse drug reactions (ADRs) for pharmacovigilance sub-Saharan Africa
 Methods: PubMed, Google Scholar Trip databases were used identify papers relevant review. ...

AIMS In Ireland there are relatively fewer adverse drug reaction (ADR/yellow card) reports from doctors in hospital than in general practice. The aim of this study was to review the attitudes to reporting of ADRs of hospital doctors and to determine the effect of making yellow cards freely available. METHODS A postal survey of actively practising doctors with follow-up of nonresponders was un...

OBJECTIVE Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of antidiabetic drugs. They inactivate incretin hormones but also have many other effects throughout the body, among which are effects on the immune system. This might result in an increased infection risk. This study assessed the association between use of DPP-4 inhibitors and the reporting of infections. RESEARCH DESIGN AND...

BACKGROUND Lack of adequate detail compromises analysis of reported suspected adverse drug reactions (ADRs). We investigated how comprehensively Ugandan healthcare professionals (HCPs) described their most recent previous-month suspected ADR, and determined the characteristics of HCPs who provided comprehensive ADR descriptions. We also identified rare, serious, and unanticipated suspected ADR ...