The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macro...

Magnesium (Mg) and its alloys have attracted considerable attention owing to their excellent biodegradable properties biocompatibility. Novel Mg–Sn–Ge ternary Mg were developed as potential materials for orthopedic applications because of alloying elements naturally present in humans. The feasibility these was investigated terms mechanical properties, degradation, cytocompatibility, hemocompati...

Surface characteristics such as roughness and contact angle of flat and nanostructured titanium samples and diamond-like carbon films (DLC) electrodeposited on the nanostructured samples were evaluated. Also, the mechanical properties and the corrosion resistance of the samples were evaluated in phosphate buffered saline (PBS). Biocompatibility was assessed by analyzing an in vitro cell culture...

Tissue Sealants In article number 2100803 by Boaz Mizrahi and co-workers, an elastic biodegradable sealant is designed mixing two complementary neat (solvent-free) star shape prepolymers. This mixture, which hardens in several seconds, offers advantages over existing tissue sealants, including excellent mechanical properties degradation behavior, minimal cytotoxicity vitro biocompatibility vivo.

background and aim:  several reports have been published on the successful application of various bone substitute materials (bsm). appropriate physiologic and histologic characteristics and reactions of these materials against host cells are critically important. in this study, the biocompatibility of a new bone substitute material has been evaluated. materials and methods: in this experimental...

The treatment of tuberculosis by chemotherapy is complicated due to multiple drug prescriptions, long treatment duration, and adverse side effects. We report here for the first time an in vitro therapeutic effect of nanocomposites based on para-aminosalicylic acid with zinc layered hydroxide (PAS-ZLH) and zinc-aluminum layered double hydroxides (PAS-Zn/Al LDH), against mycobacteria, Gram-positi...

Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute (1 day) and sub-chronic (5 days) ...