نتایج جستجو برای: vitamin k

تعداد نتایج: 465521  

2014
Jan K. Nowak Urszula Grzybowska-Chlebowczyk Piotr Landowski Anna Szaflarska-Poplawska Beata Klincewicz Daria Adamczak Tomasz Banasiewicz Andrzej Plawski Jaroslaw Walkowiak

Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to search for potential correlation between vitamin K status and pediatric IBD activit...

Journal: :Science 2012
Melissa Vos Giovanni Esposito Janaka N Edirisinghe Sven Vilain Dominik M Haddad Jan R Slabbaert Stefanie Van Meensel Onno Schaap Bart De Strooper R Meganathan Vanessa A Morais Patrik Verstreken

Human UBIAD1 localizes to mitochondria and converts vitamin K(1) to vitamin K(2). Vitamin K(2) is best known as a cofactor in blood coagulation, but in bacteria it is a membrane-bound electron carrier. Whether vitamin K(2) exerts a similar carrier function in eukaryotic cells is unknown. We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affe...

Journal: :The Biochemical journal 2013
Brian O Ingram Jared L Turbyfill Peggy J Bledsoe Anil K Jaiswal Darrel W Stafford

NQO1 [NAD(P)H quinone oxidoreductase 1; also known as DT-diaphorase] is a cytosolic enzyme that catalyses the two-electron reduction of various quinones including vitamin K. The enzyme may play a role in vitamin K metabolism by reducing vitamin K to vitamin K hydroquinone for utilization in the post-translational γ-glutamyl carboxylation reactions required by several proteins involved in blood ...

Journal: :The Journal of biological chemistry 1968
R B Hill S Gaetani A M Paolucci P B RamaRao R Alden G S Ranhotra D V Shah V K Shah B C Johnson

The role of vitamin K in the synthesis of prothrombin has been examined with the following results. 1. Vitamin K deficiency has no effect on general protein synthesis as studied by amino acid incorporation into protein in vivo and in vitro and by tryptophan pyrrolase production following tryptophan feeding. 2. Prothrombin activity was found in normal rat liver microsomes with increased release ...

Journal: :Journal of thrombosis and haemostasis : JTH 2004
K L Berkner K W Runge

Recent advances in the discovery of new functions for vitamin K-dependent (VKD) proteins and in defining vitamin K nutriture have led to a substantial revision in our understanding of vitamin K physiology. The only unequivocal function for vitamin K is as a cofactor for the carboxylation of VKD proteins which renders them active. While vitamin K was originally associated only with hepatic VKD p...

Journal: :Nutrition research 2009
Jun Iwamoto Yoshihiro Sato Tsuyoshi Takeda Hideo Matsumoto

Although systematic review and meta-analysis of randomized controlled trials (RCTs) have concluded that vitamin K is effective in preventing fractures, the effect of vitamin K on the skeleton remains a matter of controversy. The objective of the present review of the literature was to evaluate the effect of vitamin K supplementation on the skeleton of postmenopausal women. PubMed was used to se...

Journal: :Archives of disease in childhood 1987
E Ishii K Ueda

2017
A. J. van Ballegooijen J. W. Beulens

PURPOSE OF REVIEW Vitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes. RECENT FINDINGS Overa...

2016
Francesco Violi Gregory YH Lip Pasquale Pignatelli Daniele Pastori

Educational advice is often given to patients starting treatment with vitamin K Antagonists (VKAs). A great emphasis is made on nutritional information. Common belief is that dietary vitamin K intake could counteract the anticoagulant effect by VKAs and for many years, patients have been discouraged to consume vitamin-K-rich foods, such as green leafy vegetables.The objective of this study is t...

Journal: :Nutrition, metabolism, and cardiovascular diseases : NMCD 2009
G C M Gast N M de Roos I Sluijs M L Bots J W J Beulens J M Geleijnse J C Witteman D E Grobbee P H M Peeters Y T van der Schouw

BACKGROUND AND AIM Vitamin K dependent proteins have been demonstrated to inhibit vascular calcification. Data on the effect of vitamin K intake on coronary heart disease (CHD) risk, however, are scarce. To examine the relationship between dietary vitamins K(1) and K(2) intake, and its subtypes, and the incidence of CHD. METHODS AND RESULTS We used data from the Prospect-EPIC cohort consistin...

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