BACKGROUND Vitamin D deficiency has been linked to poor outcomes after total hip replacement (THR) or total knee replacement (TKR), including lower patient-reported outcome measures (PROMs), peri-prosthetic infection and longer hospital stay. We present a randomised feasibility trial protocol designed to prospectively investigate the influence of vitamin D testing, and subsequent supplementatio...

The prevalence of vitamin D insufficiency, defined by a 25-hydroxyvitamin D (25[OH]D) level 30 ng/mL, in the United States was 77% in 2004.1 Although the use of vitamin D supplementation may be increasing since 2004, it is likely that the majority of US citizens continue to have inadequate vitamin D status.2 Observational studies suggest that low 25(OH)D levels are associated with a higher risk...

background and aim: vitamin d has immune-regulatory functions in experimental inflammatory bowel disease (ibd) and vitamin d deficiency is common in ibd patients. the aim of the study was to assess the effectiveness of vitamin d 3 [1,25(oh) 2 d 3 ] treatment in ibd with regard to tumor necrosis factor-alpha (tnf-?) serum level and  clinical disease activity index (cdai). materials and methods: ...

Inadequate serum 25-hydroxyvitamin D (25[OH]D) concentrations are associated with muscle weakness, decreased physical performance, and increased propensity in falls and fractures. This paper discusses several aspects with regard to vitamin D status and supplementation when treating patients with osteoporosis in relation to risks and prevention of falls and fractures. Based on evidence from lite...

BACKGROUND Vitamin D may have a role in many chronic conditions in addition to bone health. Nutritional surveys among Americans have reported high levels of vitamin D insufficiency, especially among Blacks and Latinos. Our study examined variation in vitamin D supplementation practices in an adult health plan population by age, gender, and race-ethnicity. METHODS Self-report data from a 2008 ...

BACKGROUND Reports on the dose response to vitamin D are conflicting, and most data were derived from white men and women. OBJECTIVE The objective was to determine the response of serum 25-hydroxyvitamin D [25(OH)D] to oral vitamin D(3) supplementation in an African American population. DESIGN Healthy black postmenopausal women (n = 208) participated in a vitamin D(3) supplementation trial ...

Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...

Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation ar...

OBJECTIVE To evaluate the breadth, validity, and presence of biases of the associations of vitamin D with diverse outcomes. DESIGN Umbrella review of the evidence across systematic reviews and meta-analyses of observational studies of plasma 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D concentrations and randomised controlled trials of vitamin D supplementation. DATA SOURCES Medline, Emba...