To the Editor: Vitamin B is a water-soluble essential vitamin. A member of vitamin B complex, vitamin B is also called cobalamin because it contains the metal cobalt. Vitamin B is synthesized by bacteria and is found mainly in meat, egg, and dairy products but lacks a reliable plant source. It is essential for the formation of red blood cells and maintenance of a healthy nervous system as well ...

The effect of partial pancreatectomy (80-90%) on vitamin B(12) absorption was studied in the rat. The absorption of 5 ng of (57)Co-labeled vitamin B(12) was significantly reduced from 70 +/-2.5% (mean +/-SE) in control and sham-operated rats to 32 +/-2.6% in partially pancreatectomized rats. Hog pancreatic extract (0.17 g/kg) improved vitamin B(12) absorption from 30.0 to 61.0% in partially pan...

The transcobalamin-vitamin B(12) complex is responsible for the transport of B(12) from plasma and into the tissues. The complex is filtered in the renal glomeruli and is a high-affinity ligand for the endocytic receptor megalin expressed in the proximal tubule. This study shows by the use of the proximal tubule LLC-PK1 cell line that transcobalamin-B(12) is internalized by megalin-mediated end...

The normal human granulocyte vitamin B,,-binding protein, transcobalamin I, and transcobalamin III, have been labeled with lZSI-labeled N-succinimidyl 3-(4-hydroxyphenyl)propionate and utilized for plasma clearance studies performed with rabbits. Both moieties of 1251-labeled granulocyte vitamin B,,-binding protein[5’Co]vitamin B,, were cleared rapidly from the plasma (>90% by 5 min) by the liv...

Multiple Sclerosis (MS) is a complex neurological disease in which neuro inflammation that leads to neurodegeneration _ plays a key role and its prevalence is 2 million in the world. Vitamin A is a fat-soluble vitamin that is multifunctional. One of the important functions is in immune system, both in immunological tolerance and in adaptive immune responses. 264 patients will be enrolled that s...

XEROPHTHALMIA and malnutrition are worldwide problems, and their relationships to each other are of special interest. It is the purpose of this paper to show that: (1) Xerophthalmia occurs not uncommonly in the Republic of South Africa. Previous reports of xerophthalmia in the Republic of South Africa are few. Kark (1943) and Klenerman (1950) stated that xerophthalmia infrequently accompanies p...

In 1929 Lewy and Weisz (1) stated that persons having contact with lead exhibited an increase in the excitability of the nerves and muscles which could be demonstrated chronaximetrically several months before clinical symptoms appeared. That this method might prove valuable as a means of detecting preclinical evidence of peripheral neuritis due to vitamin B deficiency was suggested in 1934 when...