our findings is that the concentration of HC is influenced by the vitamin B12 status of the patient. The issue has important implications for the interpretation of low cobalamin in relation to low HC concentrations in patients undergoing examination for vitamin B12 deficiency. If genetic factors were the only regulators of the HC concentration, the physician could decide that the low concentrat...

Subnormal red-cell folate values were encountered in 20 of 63 thalassaemic subjects in a population with a low incidence of megaloblastosis. The abnormality was not associated with haematological changes of megaloblastosis and could not be explained on the basis of incomplete liberation of intra-erythrocytic folates, serum conjugase deficiency of vitamin B12 deficiency. Evidence is presented to...

Vitamin B12 deficiency is uncommon in pregnancy, it occurs in 10-28% of uncomplicated pregnancies, and is associated with a few complications. We present a case report of a 21-year-old patient with severe anaemia during late pregnancy caused by vitamin B12 deficiency. At 38 weeks gestation and with a BMI of 48.9, a history of rupture of membranes was given but not confirmed. On examination, she...

BACKGROUND Vitamin B12 deficiency is associated with a wide spectrum of neuro-psychiatric manifestations. RESULTS We report a case of a 44 year old female patient referred to the haematology unit with vitamin B12 deficiency presenting as an acute confusional state or delirium. Total resolution of the psychiatric symptoms occurred following parenteral vitamin B12 replacement therapy. CONCLUS...

BACKGROUND Elevated concentration of serum total homocysteine usually occurs in vitamin B-12 deficiency. This metabolite can be measured and used for screening functional vitamin B-12 deficiency. OBJECTIVES We assessed functional vitamin B12 deficiency in Tehranian elderly admitted to elderly research center, University of Social Welfare and Rehabilitation Sciences. PATIENTS AND MATERIALS A...

Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12. The aetiological profile of high serum cobalamin predominantly encompasses severe disea...

The minimal daily requirement of dietary vitamin B12 is defined as that amount which must be ingested in the diet to prevent the occurrence of megaloblastosis, anemia, or other manifestations of vitamin B12 deficiency. An attempt has been made to define this requirement by studying hematological responses to varying amounts of the vitamin in five south Indian subjects with vitamin B12 deficienc...

Urinary aminoimidazolecarboxamide (A IC), serum folate, and serum vitamin B12 values were determined in 84 apparently healthy individuals. An automated system for determination of AIC in urine is described. Despite claims to the contrary, we found no evidence of a strong relationship between elevated (e.g., >1.3 zg/mg of creatinine) AIC excretion as reflected in a casual sample of urine and fol...

An impaired awareness of hypoglycemia is a serious problem in diabetic patients, which can lead to life-threatening severe hypoglycemia. Recurrent hypoglycemia attenuates the function of the central, mainly hypothalamic, nervous system and it causes an impaired awareness of hypoglycemia. Vitamin B12 deficiency is also associated with the dysfunction of central nervous system. We report a 72-yea...

To fulfill the vitamin B12 requirement in chronic strict vegetarian or vegan fortified supplement foods are must essential as it is exclusive component of animal based food, potential neurohematological symptoms generally with anemia but could be the one without anemia in some rare cases of vitamin B12 deficiency status. This case report visualizes the common strict vegetarian neurological rela...