نتایج جستجو برای: vismodegib

تعداد نتایج: 334  

2015
Vikas Chandra Tapojyoti Das Puneet Gulati Nidhan K. Biswas Sarang Rote Uttara Chatterjee Samarendra N. Ghosh Sumit Deb Suniti K. Saha Anup K. Chowdhury Subhashish Ghosh Charles M. Rudin Ankur Mukherjee Analabha Basu Surajit Dhara

Hedgehog (Hh) signaling pathway is a valid therapeutic target in a wide range of malignancies. We focus here on glioblastoma multiforme (GBM), a lethal malignancy of the central nervous system (CNS). By analyzing RNA-sequencing based transcriptomics data on 149 clinical cases of TCGA-GBM database we show here a strong correlation (r = 0.7) between GLI1 and PTCH1 mRNA expression--as a hallmark o...

Journal: :The New England journal of medicine 2012
Aleksandar Sekulic Michael R Migden Anthony E Oro Luc Dirix Karl D Lewis John D Hainsworth James A Solomon Simon Yoo Sarah T Arron Philip A Friedlander Ellen Marmur Charles M Rudin Anne Lynn S Chang Jennifer A Low Howard M Mackey Robert L Yauch Richard A Graham Josina C Reddy Axel Hauschild

BACKGROUND Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A phase 1 study of vismodegib (GDC-0449), a first-in-class, small-molecule inhibitor of the hedgehog pathway, showed a 58% response rate among pati...

Journal: :Revista Médica de la Universidad de Costa Rica 2015

Journal: :Revista Colombiana de Hematología y Oncología 2013

Journal: :Journal of Drugs in Dermatology 2021

Basal cell carcinoma (BCC) is the most common malignancy in fair-skinned populations. Most cases are successfully treated with surgery, but advanced BCC—including locally BCC and metastatic BCC—surgery likely to result substantial morbidity or unlikely be effective. In those patients, systemic Hedgehog inhibitors (HHIs) sonidegib vismodegib only approved pharmacologic treatment option. Although...

2017
Sonia Coni Anna Barbara Mancuso Laura Di Magno Giulia Sdruscia Simona Manni Silvia Maria Serrao Dante Rotili Eleonora Spiombi Francesca Bufalieri Marialaura Petroni Monika Kusio-Kobialka Enrico De Smaele Elisabetta Ferretti Carlo Capalbo Antonello Mai Pawel Niewiadomski Isabella Screpanti Lucia Di Marcotullio Gianluca Canettieri

SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of drug resistance and tumor relapse due to novel Smo mutations. Moreover, a subset ...

Journal: :American journal of hematology 2013
Teresa S Hawley Irene Riz Wenjing Yang Yoshiyuki Wakabayashi Louis Depalma Young-Tae Chang Weiqun Peng Jun Zhu Robert G Hawley

Multiple myeloma (MM) is characterized by the malignant expansion of differentiated plasma cells. Although many chemotherapeutic agents display cytotoxic activity toward MM cells, patients inevitably succumb to their disease because the tumor cells become resistant to the anticancer drugs. The cancer stem cell hypothesis postulates that a small subpopulation of chemotherapy-resistant cancer cel...

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