We explored the host-pathogen interactions of the human opportunistic fungus Candida albicans using Drosophila melanogaster. We established that a Drosophila strain devoid of functional Toll receptor is highly susceptible to the human pathogen C. albicans. Using this sensitive strain, we have been able to show that a set of specific C. albicans mutants of different virulence in mammalian infect...

Although Yersinia enterocolitica is usually transmitted through contaminated food and untreated water, occasional transmission such as human-to-human, animal-to-human and blood transfusion associated transmission have also identified in human disease. Of the six Y. enterocolitica biotypes, the virulence of the pathogenic biotypes, namely, 1B and 2-5 is attributed to the presence of a highly con...

Background: The virulence of a pathogenic Vibrio cholerae is dependent on a discrete set of genetic determinants. In this study, we determined the distribution of virulence determinants among the clinical and environmental isolates of V. cholerae. Methods: The antibiotic resistance profiles of the isolates were determined using standard disk diffusion assay. PCR assay was performed to analyze t...

Extracellular vesicles (EVs) from human fungal pathogens have been implicated in virulence, yet little is known about their role the host-pathogen interaction. Progress has hampered by lack of a specific marker for EVs that can be used to monitor EV isolation and tracking biological systems. Here we report effect SUR7 gene knockout on production, properties, virulence Candida albicans. Sur7 com...

the genus pseudomonas consists of more than 120 species that are ubiquitous in moist environments such as water and soil ecosystems and are pathogenic to animals and humans. within the genus of pseudomonas, p. aeruginosa is most frequently associated with human infections. the bacterium is regarded as an opportunistic pathogen, primarily causing nosocomial infections in immunocompromised patien...

introduction melioidosis is a rapidly fatal infectious disease caused by burkholderia pseudomallei, an agent of potential biothreat, endemic in several parts of india. most melioidosis-induced infected aneurysms are located in the abdominal or thoracic aorta. case presentation we reported two unusual cases of melioidosis resulting in pseudoaneurysm of the descending thoracic aorta. in both case...

BACKGROUND The DevR(DosR) regulon is implicated in hypoxic adaptation and virulence of Mycobacterium tuberculosis. The present study was designed to decipher the impact of perturbation in DevR-mediated signaling on these properties. METHODOLOGY/PRINCIPAL FINDINGS M. tb complemented (Comp) strains expressing different levels of DevR were constructed in Mut1* background (expressing DevR N-termi...