نتایج جستجو برای: virf
تعداد نتایج: 157 فیلتر نتایج به سال:
Occurrence of Yersinia spp. in wild ruminants was studied and the strains were characterized to get more information on the epidemiology of enteropathogenic Yersinia in the wildlife. In total, faecal samples of 77 red deer, 60 chamois, 55 roe deer and 27 alpine ibex were collected during 3 months of the hunting season in 2011. The most frequently identified species was Y. enterocolitica found i...
Yersinia enterocolitica is a common food-borne pathogen involved in yersiniosis among humans. The present study aimed to isolate virulent Y. enterocolitica from small ruminant milk in Shahrekord, Iran. One hundred raw milk samples of 84 sheep and 16 goats were collected from different parts of Shahrekord, during fall 2015. The samples were studied by microbial method and the positive-culture sa...
RodZ regulates the post-transcriptional processing of the Shigella sonnei type III secretion system.
The expression of the type III secretion system-a main determinant of virulence in Shigella-is controlled by regulator cascades VirF-InvE (VirB) and CpxAR two-component system. A screen for mutants that restore virulence in the cpxA background led to the isolation of a mutant of rodZ, a cytoskeletal protein that maintains the rod-shaped morphology of bacilli. InvE is normally repressed at 30 °C...
LcrF (VirF), a transcription factor in the multiple adaptational response (MAR) family, regulates expression of the Yersinia type III secretion system (T3SS). Yersinia pseudotuberculosis lcrF-null mutants showed attenuated virulence in tissue culture and animal models of infection. Targeting of LcrF offers a novel, antivirulence strategy for preventing Yersinia infection. A small molecule libra...
Objectives: Detection of Yersinia enterocolitica in clinical samples is still not sensitive and fast enough. Polymerase chain reaction (PCR) offers the advantages of sensitivity, specificity, and rapidity. A two-step PCR assay to detect pathogenic Y: enterocolitica in infected tissue has been developed. Method: In the first step of the PCR assay, a general primer PCR amplification of the small ...
Kaposi's sarcoma-associated herpesvirus (KSHV) is a large double-stranded DNA gammaherpesvirus, and the etiological agent for three human malignancies: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. To establish and maintain infection, KSHV has evolved unique mechanisms to evade the host immune response. Cellular interferon regulatory factors (IRFs) are a cri...
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