Status Last revised February 1996 Previous titles/other references Validation of Virus Removal and Inactivation Procedures (III/8115/89) / CPMP/BWP/268/95 Additional Notes This guideline discusses the need for, and the contribution of, viral validation studies towards the viral safety of biological products, providing guidance on the design of a validation study including the choice of viruses ...

Phosphorylation of Tobacco mosaic virus movement protein (TMV-MP) at three carboxyterminal Ser/Thr sites negatively regulates TMV-MP gating function and viral spread in Nicotiana tabacum but not in Nicotiana benthamiana, indicating a host dependant inactivation strategy. Here, we examine the effect of mimicking carboxyterminal phosphorylation on cell-to-cell transport of TMV-MP protein itself i...

The viruses most commonly associated with food- and waterborne outbreaks of gastroenteritis are the noroviruses. The lack of a culture method for noroviruses warrants the use of cultivable model viruses to gain more insight on their transmission routes and inactivation methods. We studied the inactivation of the reported enteric canine calicivirus no. 48 (CaCV) and the respiratory feline calici...

Coronavirus disease 2019 represents a serious challenge for modern society worldwide because of the considerable and unfavourable consequences pandemic in terms human health, economics social life. In present concise survey, some essential peculiarities ozone as disinfecting therapeutic means under conditions COVID-19 reflected recent literature are described. Particularttention is paid to hosp...

An invitro study was conducted to investigate the antiviral properties of silver nanoparticles synthesized from fungal strain Aspergillus sps isolated from soil. The isolated and characterized silver nanoparticles exhibited as an excellent antiviral property on Bacteriophage viral strain. The viral inactivation process was increased with increasing the concentration of silver nanoparticles.

Antivenoms are preparations of intact or fragmented (F(ab')2 or Fab) immunoglobulin G (IgG) used in human medicine to treat the severe envenomings resulting from the bites and stings of various animals, such as snakes, spiders, scorpions, or marine animals, or from the contact with poisonous plants. They are obtained by fractionating plasma collected from immunized horses or, less frequently, s...

Ref: Retrospective Evaluation of Low-pH Viral Inactivation and Viral Filtration Data from a Multiple Company Collaboration John Mattila, Mike Clark, Shengjiang Liu, et al. PDA J Pharm Sci and Tech 2016, 70 293-299
Access the most recent version at doi:10.5731/pdajpst.2016.006478 Due to a mathematical error we would like to submit an erratum for figure 6 p298.

Southeast Asia is a significant area for world shrimp culture. However, in recent years, the production of cultured shrimp has markedly decreased as a result of serious viral disease outbreaks. Especially, the increased severity of widespread White Spot Syndrome Virus (WSSV) infection is the most serious threat to stable aquacultural production. In the case of Malaysia, outbreak of this disease...

With increasing outbreaks of gastroenteritis associated with produce, it is important to assess interventions to reduce the risk of illness. UV, ozone and high pressure are non-thermal processing technologies that have potential to inactivate human pathogens on produce and allow the retention of fresh-like organoleptic properties. The objective of this study was to determine if UV, ozone, and h...

Polychromatic UV irradiation is a common method of pathogen inactivation in the water treatment industry. To improve its disinfection efficacy, more information on the mechanisms of UV inactivation on microorganisms at wavelengths throughout the germicidal UV spectrum, particularly at below 240 nm, is necessary. This work examined UV inactivation of bacteriophage MS2, a common surrogate for ent...