Combined factor V and VIII deficiency is a rare autosomal recessive disorder with incidence of one in 10,00,000. We reported case seventy-one-year-old patient third degree uterovaginal prolapse, diagnosed as combined the successful perioperative management during vaginal hysterectomy. With our experience this, we conclude that for patient's correction should be given at least 2 weeks post opera...

The classification of factor VIII deficiency, generally used based on plasma levels of factor VIII, consists of severe (<1% normal factor VIII activity), moderate (1% to 4% factor VIII activity), or mild (5% to 25% factor VIII activity). A recent communication described four individuals bearing identical factor VIII mutations. This resulted in a severe bleeding disorder in two patients who carr...

BACKGROUND Elevated plasma levels of coagulation factor VIII are a strong risk factor for pulmonary emboli and deep venous thromboses. OBJECTIVES To identify reversible biomarkers associated with high factor VIII and assess potential significance in a specific at-risk population. PATIENTS/METHODS 609 patients with hereditary haemorrhagic telangiectasia were recruited prospectively in two se...

BACKGROUND HIV-infected patients are at increased risk of venous and arterial thrombosis. We hypothesized that acquired thrombophilic abnormalities that could predispose to thrombosis are most pronounced in patients in advanced stages of HIV infection. METHODS We included 109 consecutive HIV-infected patients in the study and tested them twice for currently known thrombophilic abnormalities a...

Hemophilia A is a disease caused by a deficiency of coagulation factor VIII resulting from genetic inheritance linked to chromosome X. One treatment option is the administration of plasma or recombinant FVIII. However, some patients develop inhibitors or antibodies against this factor. Inhibitors are alloantibodies that bind to the epitope of factor VIII causing it to be recognized by the immun...

The third member of the family of T cell leukemia viruses (HTLV III) has been proposed as the primary etiologic agent of the acquired immunodeficiency syndrome (AIDS). A high risk of AIDS has been reported among patients with hemophilia, particularly those with factor VIII deficiency who receive commercial clotting factor concentrates. In a prevalence survey conducted between September 1982 and...

Background: Data on the frequency of hereditary bleeding disorders (HBDs) and associated mortality and morbidities during a long-term follow-up from Iran are scarce. Objective: This study evaluated the epidemiologic features among patients with HBD in one of the largest referral centers in southern Iran. Methods: In this cross-secti...

INTRODUCTION and mortality seen in patients with type II diabetes mellitus is the result of microand macrovascular occlusive disease in which thrombosis plays an important part. Diabetic patients Diabetes mellitus (DM) is a metabolic syndrome characterized have lower anti thrombin III activity, protein C deficiency, by derangements in carbohydrate, protein and fat metabolism 1 increased kallikr...