Linkage disequilibrium (LD) mapping of disease genes is complicated by population- and chromosome-region-specific factors. We have analysed demographic factors by contrasting intermarker LD results obtained in a large cosmopolitan population (UK), a large genetic isolate (Sardinia) and a subisolate (village of Gavoi) for two regions of the X chromosome. A dramatic increase of LD was found in th...

A new 2xVDD-tolerant mixed-voltage I/O buffer circuit, realized with only 1xVDD devices in deep-submicron CMOS technology, to prevent transistors against gate-oxide reliability and hot-carrier degradation is proposed. The new proposed 2xVDD-tolerant I/O buffer has been designed and fabricated in a 0.13-lm CMOS process with only 1.2-V devices to serve a 2.5-V/1.2-V mixed-voltage interface, witho...

Asynchronous Transfer Mode (ATM) shared buffer switches have numerous advantages such as relatively high throughput and good buffer utilization, and they are increasingly favoured in recent VLSI switch designs. But under nonuniform traffic, the performance degrades dramatically due to the monopolization of the buffer by some favoured cells. To overcome this, restricted types of sharing and Hot-...

In this paper, we address the issue of hot-carriers and their impact on reducing the reliability of a VLSI circuit by accelerating the aging process of transistors. We tackle this phenomenon by formulating and solving an encoding problem, which we refer to as the Bit-level Transition Balancing (BTB). The BTB problem is to find encoding techniques that minimize the maximum activity over a group ...

An object o of a database D is called a hot item, if there is a sufficiently large population of other objects inD that are similar to o. In other words, hot items are objects within a dense region of other objects and provide a basis for many density-based data mining techniques. Intuitively, objects that share their attribute values with a lot of other objects could be potentially interesting...

In a previous paper (Henri & Petrucci submitted, hereafter paper I), we have derived a new model in order to explain the UV and X-ray emission of radio quiet AGNs. This model assumes that a point source of relativistic leptons (e + , e −) illuminates the accretion disk of the AGN by Inverse Compton process. This disk is supposed to be simply represented by a finite slab which radiates only the ...

We report the discovery of a faint (LX 4 1:5 ; 10 ergs s , 0.5Y2 keV), outflowing gaseous hot interstellar medium (ISM) inNGC 3379. This represents the lowest X-ray luminosity ever measured from a hot phase of the ISM in a nearby early-type galaxy. The discovery of the hot ISM in a very deep Chandra observation was possible thanks to its unique spectral and spatial signatures, which distinguish...

Shared buffer switches have many advantages such as relatively low cell loss rate and good buffer utilization, and they are increasingly favoured in recent VLSI switch designs for ATM. However, their performance degrades dramatically under nonuniform traffic due to the monopolization of the buffer by some favoured cells. To overcome this, restricted types of sharing and Hot-Spot-PushOut (HSPO) ...