We have examined the effects of a siRNA targeting the Egr-1, alone or in combination with the breast cancer therapeutic camptothecin (Cpt), in suppressing breast cancer cell survival and anchorage-independent growth in the breast cancer cell lines SK-BR3 and MCF-7. In mammary and lung tumors, as well as most normal tissues, Egr-1 expression is low, suggesting a possible relation between the low...

Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis, tumor growth, and sepsis. Endothelial cell activation, in turn, is mediated primarily at the level of gene transcription. Here, we show that in response to several activation agonists, including vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha, and thrombin, endothelial...

The necessity for dissolved oxygen in water is crucial the survival and growth of aquatic organisms, particularly tilapia. Seventy-five percent tilapia will die if there insufficient water. This work seeks to develop a venturi bubble-generating technique combat scarcity A floating pump with capacity 12 m<sup>3</sup>/hour was selected as medium distributing generating vacuum pressure...

Previously, we demonstrated that cysteamine releases endothelin-1 in the rat duodenal mucosa, followed by increased expression of early growth response factor-1 (egr-1). We hypothesized that egr-1 is a key mediator gene in the multifactorial mechanisms of duodenal ulcer development and healing because its protein, transcription factor product Egr-1, regulates the expression of angiogenic growth...

Particle collection efficiencies in 23 size intervals covering a diameter range of 0.32-2.8 pm were measured for venturi scrubbers with throat diameters of 3.2,5.4, and 7.6 cm. Each scrubber was operated with four types of liquid injection, throat gas velocities from 21 to 160 m/s, and liquid-to-gas volume ratios from 0.000 19 to 0.0043. Results were compared to three widely used theoretical mo...

BACKGROUND A table of the approximate ranges of inspired oxygen delivered at given oxygen flow rates is often given on the packaging of oxygen masks. A study was carried out to check the inspired oxygen concentration given by one of the new masks, which has been designed to be used with or without the Venturi attachment as a result of the proposal to use it without the Venturi attachment as a g...

Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis, tumor growth, and sepsis. Endothelial cell activation, in turn, is mediated primarily at the level of gene transcription. Here, we show that in response to several activation agonists, including vascular endothelial growth factor (VEGF), tumor necrosis factor, and thrombin, endothelial cells...

AIMS To understand the mechanisms of Early Growth Response Protein 1 (Egr-1) induction upon HSV-1 lytic infection and its roles in regulating viral gene expression and replication. STUDY DESIGN Rabbit corneal cell line SIRC and other cell lines were infected by HSV-1 to investigate the Egr-1 induction and its occupancy on the viral genome in different conditions. UV-inactivated HSV-1 and a re...

Thermal nuclear reactor power is typically evaluated with secondary system calorimetric calculations based on feedwater flow rate measurements. The feedwater flow rate should therefore be measured accurately. Venturi meters are currently used to measure the feedwater flow rate in most pressurized water reactors (PWRs). The long-term operation of a nuclear power plant causes a buildup of corrosi...