Genital human papillomavirus infection is one of the most common sexually transmitted diseases. Imiquimod is a new agent, an immune-response modifier, that has been demonstrated to have potent in vivo antiviral and antitumor effects in animal models. The present prospective, multicenter, double-blind, randomized, vehicle-controlled trial evaluated the efficacy and safety of daily patient-applie...

Studies have consistently shown that sleep apnea patients have high accident rates, but the generalizability of the association beyond clinic populations has been questioned. The goal of this investigation was to determine if unrecognized sleep-disordered breathing in the general population, ranging from mild to severe, is associated with motor vehicle accidents. The sample comprised 913 employ...

LP-211 is a new, selective agonist of serotonin (5-hydroxytryptamine, 5-HT) receptor 7 (5-HT7-R), which is part of a neuro-transmission system with a proposed role in neural plasticity and in mood, cognitive and sleep regulation. Adolescent subchronic LP-211 treatment produces some persisting changes in rats' forebrain structural and functional parameters. Here, using pharmacological MRI (phMRI...

Galinsky R, Lear CA, Yamaguchi K, Wassink G, Westgate JA, Bennet L, Gunn AJ. Cholinergic and -adrenergic control of cardiovascular reflex responses to brief repeated asphyxia in termequivalent fetal sheep. Am J Physiol Regul Integr Comp Physiol 311: R949–R956, 2016. First published September 16, 2016; doi:10.1152/ ajpregu.00340.2016.—The role of cholinergic and -adrenergic activity in mediating...

Methods and Results-—Male Sprague–Dawley rats were assigned randomly to the following groups: 5/6 nephrectomy (5/6Nx) with vehicle, 5/6Nx with AST-120, sham procedure with vehicle, and sham procedure with AST-120. Vehicle and AST-120 were administered for 4 weeks. Serum levels of IS were significantly increased in 5/6Nx groups. Expression of malondialdehyde, an indicator of oxidative stress, wa...

Clindoxyl Gel (Stiefel) is a combination of 1% clindamycin phosphate and 5% benzoyl peroxide in a gel vehicle that is well tolerated and more efficacious than either active agent alone or the vehicle in reducing lesion counts and improving global scores in patients with moderate acne. It was approved for once daily use in Canada in November 2001.

in this paper, multi-objective uniform-diversity genetic algorithm (muga) with a diversity preserving mechanism called the ε-elimination algorithm is used for pareto optimization of 5-degree of freedom vehicle vibration model considering the five conflicting functions simultaneously. the important conflicting objective functions that have been considered in this work are, namely, vertical accel...

Full model overview ................................................................................................................... 2 1. Notes on vehicle adoption................................................................................................... 3 a. Vehicle Fleet Aging Chain.............................................................................................. 3 b. I...