In the title racemic salt, C(6)H(13)N(2)O(+)·C(8)H(11)O(4) (-), formed from the reaction of cis-cyclo-hexane-1,2-dicarb-oxy-lic anhydride with isonipecotamide, the cations are linked into duplex chain substructures through both centrosymmetric cyclic head-to-head 'amide motif' hydrogen-bonding associations [graph set R(2) (2)(8)] and 'side-by-side' R(2) (2)(14) associations. The anions are inco...

PURPOSE The goal of this study was to investigate the effect of rocuronium and vecuronium continuous infusion on oral tissue blood flow in rabbits. MATERIALS AND METHODS We used 8 male Japan White rabbits. The infusion rates of rocuronium were 7, 14, and 28 microg kg(-1) min(-1) for 20 minutes, in this order. After rocuronium was discontinued and body movement confirmed, continuous infusion o...

In 30 children under balanced anaesthesia, we have determined dose-response curves and maintenance requirement of three dose ratio combinations of atracurium and vecuronium (10:1, 4:1 or 1.6:1 on a microgram:microgram basis). Neuromuscular block was monitored by adductor pollicis EMG. An equipotent dose ratio (4:1) was most potent, with a mean (SEM) ED95 of atracurium 95 (6) micrograms kg-1 wit...

Vecuronium was used as the only neuromuscular blocking agent in 81 paediatric patients (neonates to adolescents) during fentanyl and nitrous oxide anaesthesia. The thenar electromyogram was used to monitor neuromuscular blockade. Neonates and infants had a mean requirement of vecuronium 105 micrograms kg-1 during the first 1 h of anaesthesia, to establish and maintain 90-98% neuromuscular block...

Sugammadex sodium is a modified γ-cyclodextrin with a very high affinity for rocuronium and, to a lesser extent, vecuronium molecules. In vivo administration results in immediate encapsulation of rocuronium and vecuronium, resulting in termination of neuro- muscular blockade, usually within 3 minutes. This new neuromuscular blocking agent is specific for the aminosteroidal neuromuscular blockin...

Introduction: Priming markedly shortens the onset time to non depolarising neuromuscular blocking drugs. Magnesium inhibits presynaptic acetylcholine release at the motor end plate; hence magnesium potentiates the effect of non-depolarising muscle relaxants and shortens their onset time. Thus, the combination of priming and magnesium pre-treatment may be an alternative, effective method for acc...

The effect of vecuronium on intracranial pressure (ICP) was investigated in six cats with normal and increased ICP. Cats were anaesthetized with pentobarbitone 33 mg kg-1 i.p. and acepromazine 0.6 mg kg-1 i.p., the trachea was intubated, and the lungs ventilated with nitrous oxide in oxygen. Mean arterial pressure (MAP), heart rate (HR), twitch response and ICP were recorded continuously. After...

We have compared the degree of tetanic fade relative to twitch depression occurring after isolated forearm block with vecuronium and that after systemic i.v. injection. Fifteen patients received either vecuronium 0.3 mg into an isolated forearm or vecuronium 0.05 mg kg-1 systemically. Adductor pollicis mechanomyography was used to monitor recovery of twitch height at 0.2 Hz. At 25, 50, 75 and 1...

We studied the effect of olprinone on neuromuscular blockade caused by vecuronium. Thirty women undergoing nitrous oxide-oxygen-isoflurane anesthesia were randomly divided into olprinone (n=15) or control group (n=15). In the olprinone group, the patients received an intravenous initial loading dose of olprinone at a rate of 2 microg/kg/minute for 5 minutes, followed by a continuous infusion of...

The distribution and kinetics of 14C-vecuronium were studied in rats and mice. 14C-Vecuronium accumulated rapidly in the liver. Both unchanged and metabolized vecuronium were excreted with the bile into the intestines and stomach. Reabsorption in the gut was probably responsible for an enterohepatic increase in radioactivity in the liver after one hour. Excretion through the kidneys increased c...