INTRODUCTION Placental vascularity may be important in the development of fetal growth restriction (FGR). The overnourished adolescent ewe is a robust model of the condition, with ∼50% of offspring demonstrating FGR (birthweight >2 standard deviations below optimally-fed control mean). We studied whether placental vascularity, angiogenesis and glucose transport reflect FGR severity. METHODS S...

1. Coincident progressive and regressive changes are induced in the tail of the frog larva by simultaneous thyroid administration and removal of a portion of the tail. The rate of growth of the regenerating tail is greatest in animals not treated with thyroid, next greatest in animals treated with thyroid 2 days after tail removal, somewhat less in animals treated with thyroid simultaneously wi...

Drugs that target the tumor vasculature and inhibit angiogenesis are widely used for cancer treatment. Individual tumors show large differences in vascularity, but it is uncertain how these differences affect responsiveness to antiangiogenesis. We investigated this question using two closely related prostate cancer models that differ markedly in tumor vascularity: PC3, which has very low vascul...

OBJECTIVES Synovitis in rheumatoid arthritis (RA) is assessed clinically by the presence of joint tenderness and swelling. Synovial thickening and increased vascularity may also be detected by high-resolution ultrasonography (US) and power Doppler (PD). This study investigated the relationship between clinical and sonographic features of synovial disease utilizing US, PD and the contrast agent ...

AIM To investigate the relation between angiogenesis and inflammation in invasive carcinoma of the breast. METHODS Sections from 75 invasive carcinomas of the breast were stained using immunohistochemistry for von Willebrand factor, CD3, CD8, CD45RO, CD45RA, CD20, CD68, and c-erbB-2. Tumour vascularity was assessed by counting vessels in the three most vascular areas, and calculating the aver...

BACKGROUND We used three-dimensional power Doppler angiography (3D-PDA) to examine the periodic changes in endometrial development and subendometrial vascularity during the normal menstrual cycle in 29 women with unexplained subfertility and 19 controls. METHODS 3D-PDA was performed on alternate days from day 3 of the cycle until ovulation and then every 4 days until menses. VOCAL (Virtual Or...

BACKGROUND AND PURPOSE Although the role of gray-scale sonography for neck nodes is well documented, it plays a limited role in the evaluation of nodal response to treatment. This preliminary limited study sought to determine color duplex sonographic changes in successfully treated metastatic nodes from nasopharyngeal carcinoma. METHODS Fourteen patients with nodal metastases from nasopharyng...

Uterine fibroids are considered to be the most frequent female benign tumours. The most common reported symptoms of fibroids are heavy menstrual bleeding and painful menstruation, pelvic pain, urinary problems, constipation, as well as infertility and recurrent pregnancy loss. The mainstay of fibroid treatment is surgery, but nowadays minimally-invasive techniques are growing in popularity. Vas...

Introduction: Thyroid nodules are commonly encountered on ultrasonographic studies. Color doppler ultrasonography can be utilized to help in differentiating malignant and nonmalignant nodules based on different imaging criteria. Objective: The objective of this study is to correlate sonographic and color Doppler characteristics of thyroid nodules with the results of sonographically guided fine-...