This paper deals with the problem of testing statisticalhypotheses when the available data are fuzzy. In this approach, wefirst obtain a fuzzy test statistic based on fuzzy data, and then,based on a new signed distance between fuzzy numbers, we introducea new decision rule to accept/reject the hypothesis of interest.The proposed approach is investigated for two cases: the casewithout nuisance p...

In this paper the detection of rare variants association with continuous phenotypes of interest is investigated via the likelihood-ratio based variance component test under the framework of linear mixed models. The hypothesis testing is challenging and nonstandard, since under the null the variance component is located on the boundary of its parameter space. In this situation the usual asymptot...

We consider the problem of testing for zero variance components in linear mixed models with correlated or heteroscedastic errors. In the case of independent and identically distributed errors, a valid test exists, which is based on the exact finite sample distribution of the restricted likelihood ratio test statistic under the null hypothesis. We propose to make use of a transformation to deriv...

In this paper the detection of rare variants association with continuous phenotypes of interest is investigated via the likelihood-ratio based variance component test under the framework of linear mixed models. The hypothesis testing is challenging and nonstandard, since under the null the variance component is located on the boundary of its parameter space. In this situation the usual asymptot...