Family structure, lack of reliable information, cost, and delay are usual concerns when deciding to perform BRCA analyses. Testing breast cancer tissues with four antibodies (MS110, lys27H3, vimentin, and KI67) in addition to grade evaluation enabled us to rapidly select patients for genetic testing identification. We constituted an initial breast cancer tissue microarray, considered as a learn...

The histopathological diagnosis of melanoma can be challenging. No currently used molecular markers accurately distinguish between nevus and melanoma. Recent transcriptome analyses have shown the differential expression of several genes in melanoma progression. Here, we describe a multi-marker diagnostic assay using 5 markers (ARPC2, FN1, RGS1, SPP1, and WNT2) overexpressed in melanomas. Immuno...

Background: Recent biotechnological developments have resulted in increasing interest in immunology biomarkers. These biomarkers have potential clinical utility in the near future as predictors of treatment response. Hence, clinical validation of these predictive markers is critical. Findings: The process of clinically validating a predictive biomarker is reviewed. Validation of a predictive bi...

Maize streak virus (MSV) is responsible for disease of maize and poses a serious threat to production in sub-Saharan Africa. Polygenic resistance MSV has become an essential requirement modern cultivars mitigate yield losses. Many single nucleotide polymorphism (SNP) markers linked putative loci have been identified use forward breeding. This study aimed validate, using the high-throughput komp...