Bilateral diffuse uveal melanocytic proliferation is a rare paraneoplastic syndrome that presents with bilateral progressive loss of vision. A 70-year-old woman presented with a 3-month history of progressive, bilateral vision loss. The patient had bilateral, diffuse, shallow, subretinal fluid with patchy, reddish-brown lesions at the level of the retinal pigment epithelium (RPE) that showed si...

1 US Food and Drug Administration. Topamax (topiramate) tablets prescribing information. Available from: http://www.fda.gov/medwatch/ SAFETY/2003/topamax.htm / http://www.fda.gov/medwatch/ SAFETY/2003/topamax.htm [last accessed on 2007 Mar 30]. 2 Angehagen M, Ben-Menachem E, Rönnbäck L, Hansson E. Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine and topiramate. Neu...

This report details a family in whom there is autosomal dominantly inherited uveal colobomata, associated eye defects, and cleft lip and palate occurring in twelve subjects over three generations. Considerable variability in expression of the gene is apparent, uveal colobomata being the most constant feature, and the full syndrome probably includes mental retardation of varying degree. The poss...

Most multiple congenital abnormality syndromes associated with uveal colobomata have their origins dating from before intrauterine development. Causative genetic and chromosomal influences were reviewed (James, Karseras, and Wybar, 1974), but associated abnornalities of the sex chromosomes were not observed in their series and are a rare occurrence in the literature. It is of interest therefore...

Bilateral diffuse uveal melanocytic hyperplasia (BDUMH) is a rare but well known paraneoplastic syndrome,' associated with systemic malignancy. An essential feature of this syndrome is a preponderantly benign looking cytology of the melanocytic tumours.' We describe the clinical and histopathological features ofBDUMH with active proliferation and bilateral ciliary body malignant melanomas. The ...

BACKGROUND AND OBJECTIVES Features and characteristics of uveal melanoma are well described in adults, but little is known about the presentation of uveal melanoma in infancy. DESIGN Systematic literature review. METHODS A review of published, peer-reviewed literature reporting on uveal melanoma presenting during the first two years of life. Outcome measures included demographics, clinical ...

Isolated pleural effusion, so called primary pleural effusion denotes a pleural effusion without documented etiology such as a cardiac, inflammatory, iatrogenic problem or fetal hydrops. Chromosomal anomaly such as Down syndrome may be associated with isolated pleural effusion. The content of the isolated pleural effusion is mostly chylous, and isolated non-chylous pleural effusion in neonate i...