Bone marrow transplantation is called hematopoetic stem cell transplantation (HSCT), since peripheral blood and umbilical cord blood can also be used as sources of stem cell currently. In children, bone marrow transplantation is used as a definite treatment method in many diseases including hemoglobinopaties, immune deficiencies, bone marrow failure and congenital metabolic diseases in addition...

during the last two decades conventional therapy has improved the prognosis of thalassemia. however, despite such improvement it still remains a progressive disease with treatment-related complications such as hepatitis, liver fibrosis, and cardiac disease. bone marrow transplantation (bmt) can prevent or delay progression of the aforementioned complications. the importance of clinical research...

during april, 1991 and september, 1993, eighteen patients with major thalassemia admitted to shariati bmt center. seventeen patients were transplanted were from hla identical siblings and one from. his hla identical father. eleven of the donors were the known cases of minor thalassemia. the range of patients' age was within 3-10 years (with the average of 5 years and 11 months). among them...

background bone marrow transplantation (bmt)is nowadays used in various hematological disorders including leukemias. hemophilia a & b are sex linked bleeding disorders in which there are various genetic abnormalities in factor viii & ix genes. among various hematological disorders, bleeding disorders mainly hemophilia in now widely treated using plasma derived and recombinant factor viii & ix c...

Bone marrow transplantation is a potentially curative treatment for patients with leukemia, aplastic anemia, metabolic disorders, and immunodeficiency. One of the main problems ofthis procedure is the graftversus-host reaction induced in the recipient by the immune function of the transplanted marrow. In order to minimize the risks of graft rejection and graft-versus-host disease (GVHD), marrow...

Under specific conditions, bone marrow cells can transdifferentiate into a variety of cell types including hepatocytes. In this study, bioencapsulated bone marrow cells were transplanted intraperitoneally into 90% hepatectomized rats. We then followed the transdifferentiation of the bone marrow cells and the effect of this on liver regeneration in this liver failure model. Bone marrow cells iso...

INTRODUCTION Transplantation of hematopoietic stem cells from blood or bone marrow has become accepted therapy for many diseases. Numbers of transplants have increased significantly and stem cell source, donor type and indications have changed during this decade. Information on these changes is essential for interpretation of current data, patient counseling and health care planning. PATIENTS...

Background: Protection of hematopoietic system has become a primary goal in the development of novel medical countermeasures against ionization radiation and radiotherapy. This study was to explore the role of rapamycin in normal tissues against radiation. Materials and Methods: Mice were pretreated with rapamycin by i.p. every other day for five times before 5 Gy or 8.5 Gy γ-ray whole bo...

BACKGROUND CD40 ligand (CD40L) deficiency is a rare X linked immunodeficiency disorder leading to recurrent bacterial infection, with cryptosporidial enteritis and subsequent hepatic cirrhosis. Bone marrow transplantation offers the only cure. OBJECTIVE To analyse retrospectively the outcome of bone marrow transplantation for this condition in one centre. DESIGN A retrospective case note an...