BACKGROUND Pelvic pain is a common gynecologic problem. We report a case of a noncommunicating accessory uterine cavity as a cause of pelvic pain in a young adolescent. CASE A 17-year-old nulligravida presented with worsening pelvic pain. Transvaginal ultrasound revealed a 3-cm cavity within the myometrium. Hysteroscopy revealed a normal uterine cavity. Surgical excision of the accessory cavi...

OBJECTIVE To determine expression of the P2X(7) receptor in normal and in cancer uterine tissues. The rationale was that the receptor P2X(7) regulates constitutive apoptosis in uterine epithelial cells, and previous studies showed diminished P2X(7)-mediated apoptosis in cancer uterine cells compared with normal cells. METHODS A clinical, experimental feasibility study. Normal (n = 42) and can...

Remodeling of reproductive organs during pregnancy requires degradation and resynthesis of structural barriers to cell invasion. Matrix metalloproteinases (MMPs) are enzymes that break down components of the extracellular matrix (ECM) and are essential for tissue remodeling processes. Tissue inhibitors of metalloproteinases (TIMPs) are important regulators of MMP activity. In the pig, relaxin s...

The endogenous concentrations and subcellular distribution of estrone and estradiol were measured in malignant and nonmalignant human breast tissue from pre- and postmenopausal women. The most striking finding was the significantly higher concentration of estradiol per g of tissue in the malignant tissues than in the nonmalignant tissues. The tissue concentrations of estradiol in pre- and postm...

The endogenous concentrations and subcellular distribution of estrone and estradiol were measured in malignant and nonmalignant human breast tissue from preand postmenopausal women. The most striking finding was the significantly higher concentra tion of estradiol per g of tissue in the malignant tissues than in the nonmalignant tissues. The tissue concentrations of estradiol in preand postmeno...

BACKGROUND Ghrelin is a hormone which has effects on the secretion of growth hormone, the gastrointestinal system, the cardiovascular system, cell proliferation and the reproductive system. OBJECTIVES The aim of this study is to investigate structural changes in the uterine tissue and to assess ghrelin immunoreactivity in the endometrium as a result of bilateral ovariectomization of rats. M...

Uterine leiomyosarcoma (ULMS) is an uncommon malignancy that accounts for one-third of uterine sarcomas and represents 1% of all uterine malignancies, with an incidence averaging 0.5-1/100,000/year. The prognosis is poor due to its intrinsic aggressiveness and its characteristic high metastatic potential with reported distant metastatic spread in lung, abdomen, soft tissue, and brain. We presen...