Changes in serum immunoreactive (IR)-inhibin were measured by RIA in two studies, in order to elucidate, firstly whether the pattern of IR-inhibin secretion is similar to that of estradiol (E2), and secondly, whether inhibin suppresses endogenous FSH release. Study 1: Purified urinary FSH (pFSH) or human menopausal gonadotropin (hMG) were daily injected intramuscularly into women with hypogonad...

We thank Miss Elena Altieri for urinary pregnanediol determinations, Mrs. Elizabeth Grassau for help with the manuscript, and Mr. Rene Roy for photography and illustrations. The compounds used in this study were generously supplied as follows: Synthetic FSH/LH-RH (AY-24031) from Dr. M. Gahwyler, Ayerst International, New York, N.Y., U.S.A., Medroxy. progesterone Acetate (Depo-Provera) The Upjoh...

Patient A was a 30-year-old white woman with a longstanding history of primary amenorrhea and infertility. By age 18 the patient had neither menstruated nor demonstrated evidence of normal breast development. At that time she was given oral contraceptives for four cycles and responded with normal vaginal bleeding. Laboratory evaluation at age 18 demonstrated a serum FSH (follicle-stimulating ho...

Exposure to elemental mercury (Hg) vapour results in an accumulation of Hg in the pituitary, the thyroid, and the testis. In this study, basal serum concentrations of pituitary hormones (thyrotrophin (TSH), prolactin (PRL), follicle stimulating hormone (FSH), and luteinising hormone (LH] or their response after administration of thyrotrophin and gonadotrophin releasing hormones did not differ b...

A 21 -year-old man with Prader-Willi syndrome (PWS) was hospitalized due to hyperglycemia. After diet therapy and transient insulin administration, his blood glucose levels improved. Based on the fact that his urinary C-peptide levels increased, the diabetes mellitus may have been due to insulin resistance with obesity. In addition, his testes had become atrophied. Testosterone levels remained ...

BACKGROUND Studies on experimental animals have found that organophosphate (OP) pesticides may act as endocrine disruptors; however, their effects on the human hormonal profile have not yet been adequately characterized. We evaluate the association between exposure to OP pesticides, measured through dialkyl phosphate (DAP) metabolites urinary levels, and the male hormone profile. METHODS A cr...

are specifically radioimmunoassayed, and urinary androgens determined by gas chromatography. Spermatogenesis is determined using spermocytograms or by testis biopsy ; LHRH and TRH tests are used. In the second part of the study, 18 infertile men having high prolactin levels are treated with bromocriptine for one month (5 mg/day), and the above tests repeated during the treatment. Using spermogr...

A 21 years old girl presented in Gyne OPD of Lady Aitchison Hospital Lahore with complaint primary amenorrhea. There was no cyclical dysmenorrhea, urinary retention or feeling abdomino pelvic mass. Her mother had menarche at 14 age. height 5 feet and one inch. secondary sexual characteristics were normal (female) well developed, external genitalia female rudimentary vagina.Ultrasound showed siz...