Activated Ca(2+)-sensing receptors (CaR) play key roles in the regulation of whole-body calcium metabolism by inhibiting the secretion of the key calcitropic hormone parathyroid hormone and promoting urinary calcium excretion. We have now examined the effects of intravenous administration of novel calcium receptor activators on renal function in anaesthetized female Wistar rats. The type II cal...

BACKGROUND The metabolic syndrome (MS) is associated with increased prevalence of kidney stones, yet the specific stone type remains largely unknown. This study was conducted to assess whether risk factors associated with calcium nephrolithiasis increase with individual characteristics of the MS. METHODS A retrospective analysis was performed in 109 non-stone-forming subjects and 128 recurren...

Blood pressure was measured in the north and in the south of the People's Republic of China in 1002 men and 1006 women. The 24-hour urinary excretion of sodium, potassium, calcium, magnesium, and creatinine was measured, and the relationship between urinary cations and blood pressure was studied. Blood pressure and 24-hour sodium excretion were higher in northern China than in southern China. W...

BACKGROUND Cadmium (Cd) can cause renal damage and osteoporosis after high-level exposure. Recently such effects, including increased urinary excretion of calcium, have been shown also at low-level exposure, as measured by Cd in blood or urine. However, associations with kidney Cd have not been examined. The aim of this study was to explore the relation between kidney Cd and urinary calcium exc...

The majority of urinary stones in children are composed of calcium oxalate. To investigate the interaction between urinary calcium, oxalate, and citrate as major risk factors for calcium stones formation, their 24-h urinary excretion was determined in 30 children with urolithiasis and 15 normal healthy children. The cutoff points between children with urolithiasis and healthy children, accuracy...

BACKGROUND AND OBJECTIVES Despite the important role of vitamin D in maintaining bone health, many clinicians are reluctant to treat vitamin D deficiency in kidney stone formers because of the theoretical risk of increasing urinary calcium excretion. This study examined the effect of vitamin D repletion on urinary calcium excretion among stone formers. DESIGN, SETTING, PARTICIPANTS, & MEASURE...

Of 50 patients with urinary calculi, upper tract stones were common between 15-44 and lower tract stones between 0-14 and above 44 years of age. Urinary calculi contained calcium, phosphate, oxalate, urate/uric acid, ammonium, magnesium and carbonate. The frequency of occurrence of each of these radicals in sixty stones was 93.33, 83.33, 61.67, 51.67, 25.00 and 13.33% respectively. Five (27.78%...

Incidence of urinary calculi and its composition have been showing a remarkable global variation with profound changes in living standards and dietary habits. Indian urinary stone composition is usually different from that of the western countries. Urinary calculi in northern India were composed of pure calcium oxalate monohydrate (COM) and pure calcium oxalate dihydrate (COD) and in Bihar were...

OBJECTIVE To assess the efficacy of 24-hour urinary protein and calcium for the prediction of preeclampsia. MATERIALS AND METHODS Two hundred normotensive women at 20-28 weeks' gestation were enrolled in the study. All women were asked to collect a 24-hour urine sample. Urinary protein and calcium were measured and expressed as milligrams per 24 hours. Sensitivity, specificity and predictive ...

Recent dietary life involves frequent opportunities for the ingestion of purified, processed food products and preserved foods, and it has been pointed out that the current dietary mineral intake strongly tends toward nutritional imbalance. The Ryukyu Islands yield coral which contains calcium and magnesium in a content ratio of about 2 to 1, with their approximate contents of 20 and 10%, respe...