UNLABELLED BACKGROUND Jack bean urease (EC 3.5.1.5) is a metalloenzyme, which catalyzes the hydrolysis of urea to produce ammonia and carbon dioxide. The heavy metal ions are common inhibitors to control the rate of the enzymatic urea hydrolysis, which take the Hg2+ as the representative. Hg2+ affects the enzyme activity causing loss of the biological function of the enzyme, which threatens ...

This study was aimed to evaluate the antioxidative and urease inhibitory properties of the extracts from Citrullus colocynthis L. The extracts of the root and pulp of fruit were prepared by soxhlet apparatus in methanol as solvent. The antioxidative activities, including DPPH radical scavenging activity, reducing power and total antioxidant activity were studied in vitro. The ...

INTRODUCTION The sensitivity of invasive diagnostic methods for Helicobacter pylori (H. pylori) infection, particularly of urease rapid test, is decreased in cases of gastroduodenal ulcer and upper gastrointestinal bleeding. OBJECTIVES To assess the influence of blood in the stomach or recent bleeding endoscopic signs in the diagnostic sensitivity of urease rapid test among patients with blee...

Winter wheat is a widely cultivated crop that requires high inputs of nitrogen (N) fertilization, which often connected with N losses. The application fertilizers nitrification (NI) and urease inhibitors (UI) an opportunity to eliminate the risk losses improve availability plants. aim this study compare effect conventional containing nitrogen-transformation as well evaluate timing their on whea...

Sulfonamide derivatives serve as an important building blocks in the drug design discovery and development (4D) process. Ciprofloxacin-, sulfadiazine- and amantadine-based sulfonamides were synthesized as potent inhibitors of jack bean urease and free radical scavengers. Molecular diversity was explored and electronic factors were also examined. All 24 synthesized compounds exhibited excellent ...

Omeprazole and lansoprazole are proton pump inhibitors that have shown activity against Helicobacter pylori and other Helicobacter species when tested by agar dilution. Lansoprazole was more active against H. pylori than was omeprazole, and the activity was independent of urease production. Disk susceptibility tests and agar dilution MIC determinations were performed to investigate the effects ...

The application of urea fertilizer has always been associated with heavy N losses therefore, improving its efficiency is critical to minimize economic and environmental losses associated with its application. One possible approach to improve the nitrogen losses from the surface applied urea is to coat it with sulfur, urease inhibitor (agrotain) and other biodegradable materials. A pot experimen...

The ability of Helicobacter pylori to survive in the varying acidity of the stomach is considered to be linked to its ability to maintain a tolerable pH in its periplasmic space by acid dependent activation of internal urease activity. Whereas survival of H pylori can occur between a periplasmic pH of 4.0 to 8.0, growth can only occur between a periplasmic pH of 6.0 to 8.0. When urease activity...