BACKGROUND Our aim was to determine whether lymphangiogenesis occurs in the early steps of cancerogenesis of the upper aerodigestive tract. METHODS We assessed the number of lymphatics per unit area (lymphatic vascular density [LVD]) and the percent area occupied by the lymphatic vessels (lymphatic vascular area [LVA]) by computer-assisted morphometric analysis in 56 samples immunohistochemic...

Outdoor air pollution has been recently classified as a class I human carcinogen by the World Health Organization (WHO). Cumulative evidence from across the globe shows that polluted air is associated with increased risk of lung, head and neck, and nasopharyngeal cancers--all of which affect the upper aerodigestive tract. Importantly, these cancers have been previously linked to smoking. In thi...

UNLABELLED Because of the proximity of vital structures, certain complications are inherent to neck dissection (ND) for the treatment of patients with squamous cell carcinoma of the upper aerodigestive tract. AIM To establish the incidence of complications of ND. METHODS A cross-sectional retrospective study of patient registries. ND with curative intention was evaluated in 480 patients wit...

The field cancerization hypothesis suggests that carcinogen exposure affects the entire epithelial lining of the lungs and upper aerodigestive tract. The concept that common exposures place the entire epithelium at risk for the development of invasive cancer is supported both by the occurrence of premalignant lesions such as leukoplakia and squamous metaplasia, and by the development of multipl...

introduction: foreign bodies in the upper aerodigestive tract often get lost following inappropriate attempts at removal. children may present late with localized infection, posing a challenge to the otolaryngologists in a referral set-up in diagnosing and retrieving such foreign bodies.   case report: a two-year-old boy presented with refractory purulent rhinorrhea and intermittent low-grade f...

IntroductionPleomorphic adenoma (PA) is the most common benign tumor of major salivary glands. It may also arise from minor glands upper aerodigestive tract. PA auditory canal a rarity. The earlier hypothesis that originates ectopic gland tissue has not yet been proven. Currently it assumed external myoepithelia local ceruminal accordingly classified by WHO as adenoma. tendency to recurrence an...

BACKGROUND Tobacco use increases the risk for squamous cell carcinoma (SCC) of the upper aerodigestive tract. The reported incidence of synchronous second primary tumors in head and neck cancer is approximately 10%. Therefore, patients with oral cancer have routinely undergone "panendoscopy" consisting of direct laryngoscopy, bronchoscopy, and esophagoscopy. Recent studies indicate increasing n...