objectives the present study aimed to evaluate the genotypes and prevalence of mutations in a segment of s and rt gene in hbv isolates in southern khorasan, iran. methods this was a population-based study comprising 5,235 randomized samples for hbv screening. a nested-polymerase chain reaction (pcr) test was followed by direct sequencing, and the sequences blast with present sequences of ncbi d...

BACKGROUND Scoliosis is a feature of several genetic disorders that are also associated with aortic aneurysm, including Marfan syndrome, Loeys-Dietz syndrome, and type-IV Ehlers-Danlos syndrome. Life-threatening complications of aortic aneurysm can be decreased through early diagnosis. Genetic screening for mutations in populations at risk, such as patients with adolescent idiopathic scoliosis,...

background: disorders of sex development (dsds) belong to uncommon pathologies and result from abnormalities during gonadal determination and differentiation. various gene mutations involved in gonadal determination and differentiation have been associated with gonadal dysgenesis. despite advances in exploration of genes and mechanisms involved in sex disorders, most children with severe 46,xy ...

We find M-theory (Type IIA) duals for compactifications of the 9d CHL string to 5d (4d) on K3 (K3 × S 1). The IIA duals are Calabi-Yau orbifolds with nontrivial RR U (1) In ten dimensions, the consistent critical string theories with (at least) sixteen super-charges have been known since the 1980s. There are (after accounting for the S-duality of the two SO(32) theories) four. In D = 9, in addi...

Dyskeratosis congenita (DC) is a genetic disorder of defective tissue maintenance and cancer predisposition caused by short telomeres and impaired stem cell function. Telomerase mutations are thought to precipitate DC by reducing either the catalytic activity or the overall levels of the telomerase complex. However, the underlying genetic mutations and the mechanisms of telomere shortening rema...

We present a unified approach to quantum teleportation in arbitrary dimensions based on the Wigner-function formalism. This approach provides us with a clear picture of all manipulations performed in the telepor-tation protocol. In addition within the framework of the Wigner-function formalism all the imperfections of the manipulations can be easily taken into account. All quantum mechanical ph...

Recently, whole genome sequencing approaches have pinpointed mutations in genes that were previously not associated with cancer. For Acute Myeloid Leukaemia (AML), and other myeloid disorders, these approaches revealed a high prevalence of mutations in genes encoding the chromosome cohesion complex, cohesin. Cohesin mutations represent a novel genetic pathway for AML, but how AML arises from th...

Chronic, excessive exposure to solar ultraviolet radiation is the major causative agent for cutaneous squamous cell carcinomas. Mutations in p53 are essential these cancers develop. UV also immunosuppressive and an additional requirement UV-induced SCCs can be reversed with compound CP31398, which results fewer mice exposed a skin carcinogenesis protocol. It unknown whether mutations contribute...