The whole blood concentrations of 22 amino acids were measured in a chronic, unstressed fetal lamb preparations. Samples were taken daily from the umbilical artery, umbilical vein, and maternal artery over the latter quarter of gestation. 73 sets of samples (from the umbilical artery and vein and the maternal artery) from 13 animals were analyzed for amino acid levels. Oxygen contents were dete...

neonatal sepsis is an important cause of death and morbidity in newborns and is diagnosed by isolation of organism in blood culture. in several reports,reliablity of blood cultures were done from umbi lical catheters,have been demonstrated. the objective of the present study was to determine,wether an inde welling umbilical catheter, could be an alternative site for blood culture. in a prospect...

Importance Fetal umbilical vein aneurysm is an uncommon anomaly that accounts for approximately 4% of umbilical cord abnormalities. The rate of intrauterine fetal death is reported to be approximately 4% to 5%, higher than the background rate of 0.7% that is generally reported during pregnancy. Objective The aim of this study was to review the pathophysiology, diagnosis, and clinical manageme...

Umbilical and supraumbilical catheter insertion is a common procedure performed in the NICU. It is a safe and usually easy procedure devoid of serious mishaps, morbidity and mortality. Complications such as hemorrhage, infection, hernia, evisceration, omphalitis, portal vein thrombosis and portal hypertension may occur after umbilical catheter insertion. Other uncommon and rare complications re...

Received May 19, 2001 Abstract We report a premature newborn who developed circulatory collapse 46 hours after birth due to cardiac tamponade. Echocardiography revealed large circumferential pericardial effusion. Pericardiocentesis yielded 12 ml of clear straw-colored fluid with high glucose level of 102.9 mmol/L. The neonate improved after the procedure. Pericardial tamponade is a rare complic...

The impact of Listeria monocytogenes listeriolysin O (LLO) secretion on phosphoinositide metabolism and mediator (platelet-activating factor and prostaglandin I2) generation was investigated in human umbilical vein endothelial cells. Wild-type L. monocytogenes, purified LLO, and an L. innocua strain engineered to secrete LLO all elicited a strong response, whereas mutant strains defective in LL...

To study the molecular mechanism of action of ligustrazine, a low-density oligonucleotide microarray for cardiovascular disease-related genes, was constructed, and the preparation and hybridization protocols were optimized. Under the optimized conditions, the molecular mechanism of action of ligustrazine was analyzed with human umbilical vein endothelial cells. After 4 h of treatment with 100 m...

Dihydrotanshinone I (DI), a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, has been reported to have cytotoxicity to a variety of tumor cells. In this study, we investigated its anti-angiogenic capacity in human umbilical vein endothelial cells. DI induced a potent cytotoxicity to human umbilical vein endothelial cells, with an IC(50) value of approximately 1.28 microg/m...