Volume overload in heart failure (HF) results from neurohumoral activation causing renal sodium and water retention secondary to arterial underfilling. Volume overload not only causes signs and symptoms of congestion, but can impact myocardial remodeling and HF progression. Thus, treating congestion is a cornerstone of HF management. Loop diuretics are the most commonly used drugs in this setti...

Heart failure remains the leading cause of hospitalization in older patients and is considered a growing public health problem with a significant financial burden on the health care system. The suboptimal efficacy and safety profile of diuretic-based therapeutic regimens coupled with unsatisfactory results of the studies on novel pharmacologic agents have positioned ultrafiltration on the foref...

BACKGROUND Patients on long-term treatment with peritoneal dialysis (PD) suffer from increasing peritoneal permeability and loss of ultrafiltration as a result of persistent inflammation, which may be triggered by bioincompatible dialysis fluids. Heparins have anti-inflammatory and anticoagulant properties. We have examined the effect of intraperitoneal (IP) low-molecular weight heparin (tinzap...

Cross-flow ultrafiltration of macromolecular solutions in a module with microchannels is expected to have the advantages of fast diffusion from the membrane surface and a high ratio of membrane surface area to feed liquid volume. Cross-flow ultrafiltration modules with microchannels are expected to be used for separation and refining and as membrane reactors in microchemical processes. Though t...

BACKGROUND Quantification of bioactive, free serum cortisol concentrations can characterize adrenocortical function more appropriately compared to total serum cortisol measurement. Ultrafiltration or equilibrium dialysis of serum samples allow direct measurement of free serum cortisol concentrations but respective methods have poorly been validated so far. The aim of our study was to investigat...

The use of ultrafiltration technology for municipal drinking water applications is a relatively recent concept, although in the beginning, it is already commonly used in many industrial applications such as food or pharmaceutical industries. Ultrafiltration is proven to be a competitive treatment compare with conventional ones. In some cases, the combination of ultrafiltration with conventional...

a neuro-fuzzy modeling tool (anfis) has been used to dynamically model cross flow ultrafiltration of milk. it aims to predict permeate flux and total hydraulic resistance as a function of transmembrane pressure, ph, temperature, fat, molecular weight cut off, and processing time. dynamic modeling of ultrafiltration performance of colloidal systems (such as milk) is very important for designing ...