background diabetic foot ulcer is a worldwide health care concern affecting tens of thousands of patients. if these ulcers left untreated, they can create severe complications. objectives this study was designed to examine the effect of infrared radiation on the healing of diabetic foot ulcer. patients and methods this clinical trial was performed on 50 patients referred to dr. ganjavian hospit...

DHC-1, a herbal formulation, was tested for its anti-ulcer and antioxidant activity in rats. Effect of various doses (125, 250, 500, and 1000 mg/kg, p.o.) of DHC-1 was studied on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol-induced gastric mucosal injury in rats. The reduction in ulcer index in both the models along with the reduction in volume and total acidity, and ...

Objective: In this study, we elucidated the ameliorative effect of aqueous extract of leaves of Mumiju against acetic acid-induced experimental colitis in male rats. Materials and Methods: The animals were randomly divided into four groups (n=7) including I: control group, II: vehicle group (injected with 2 ml acetic acid (4%) intra rectally), III and IV: treatment groups which received Mumiju ...

Helicobacter pylori infection, excessive consumption of alcohol and the prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDS) are the major factors that cause peptic ulcer. Previous studies from our lab revealed the potency of the ethanol extract of the plant, Cardiospermum halicacabum Linn. against ethanol induced gastric ulcerogenesis in rats. The present study intended to compare th...

In order to establish a reliable method for the production of gastric antral ulcer in rats, combined treatments with three factors: a vagal stimulant, a mucosal barrier breaker and a necrotizing agent were investigated. By the combined administration of 2-deoxy-D-glucose (2-DG; 200 mg/kg, i.v.), aspirin (100-400 mg/kg, p.o.) and hydrochloric acid (0.15 and 0.35 N, 0.5-1.5 ml/100 g, p.o.) or amm...

The aim of this study was to compare five types of compression therapy in venous leg ulcers (intermittent pneumatic vs. stockings vs. multi layer vs. two layer short stretch bandages vs. Unna boots). Primary study endpoints were analysis of changes of the total ulcer surface area, volume and linear dimensions inside observed groups. The secondary end points were comparisons between all groups t...

The present study was designed to compare ulcer protective effect of proton pump inhibitors viz. omeprazole, rabeprazole and lansoprazole against dexamethasone plus pylorus ligation induced ulcer model. Dexamethasone (5 mg/kg) was used as an ulcerogen. Dexamethasone suspended in 1% CMC in water was given orally to all the rats 15 min after the pylorus ligation. Omeprazole (20 mg/kg), rabeprazol...

The   stembark of Mammea africana is used traditionally for the treatment of stomach pains. The present study was designed to evaluate the effects of ethanolic stembark extract of Mammea africana on experimentally induced diarrhoea and ulcer . The extract ( 30 – 90mg/kg) was administered orally in rats 30 minutes to one hour before the induction of diarrhoeal and ulcer using di...

Vanillin is commonly used as an additive in food, medicine and cosmetics, but its effect has not yet been studied in gastric injury. Therefore the effect of vanillin was studied in experimental gastric ulcer. Gastric secretion and acidity were studied in pylorus ligated rats. Ulcer index, levels of gastric mucus, malondialdehyde (MDA), myeloperoxidase activity (MPO), expression of nuclear facto...