نتایج جستجو برای: uhplc

تعداد نتایج: 1632  

Journal: :Trends in Analytical Chemistry 2023

Metabolomics is an interdisciplinary field with applications in many areas. Analytes include metabolites involved pathways such as glycolysis, amino acid metabolism, the Krebs cycle, etc. However, these biosynthetic are typically highly polar molecules, which represent a major challenge for chromatographic analysis. Whilst there have been significant efforts to address difficulties determinatio...

Journal: :Molecules 2013
Cindy F Verdu Julia Gatto Ingrid Freuze Pascal Richomme François Laurens David Guilet

The aim of this study was to develop faster and more efficient phenotyping methods for in-depth genetic studies on cider apple progeny. The UHPLC chromatographic system was chosen to separate polyphenolic compounds, and quantifications were then simultaneously performed with a UV-PDA detector and an ESI-triple quadrupole mass analyzer (SRM mode). Both quantification methods were validated for 1...

Journal: :TrAC Trends in Analytical Chemistry 2014

Journal: :Journal of lipid research 2012
Samuel L M Arnold John K Amory Thomas J Walsh Nina Isoherranen

Retinol (vitamin A) circulates at 1-4 μM concentration and is easily measured in serum. However, retinol is biologically inactive. Its metabolite, retinoic acid (RA), is believed to be responsible for biological effects of vitamin A, and hence the measurement of retinol concentrations is of limited value. A UHPLC-MS/MS method using isotope-labeled internal standards was developed and validated ...

2016
Daisuke Saigusa Yasunobu Okamura Ikuko N Motoike Yasutake Katoh Yasuhiro Kurosawa Reina Saijyo Seizo Koshiba Jun Yasuda Hozumi Motohashi Junichi Sugawara Osamu Tanabe Kengo Kinoshita Masayuki Yamamoto

Metabolomics is a promising avenue for biomarker discovery. Although the quality of metabolomic analyses, especially global metabolomics (G-Met) using mass spectrometry (MS), largely depends on the instrumentation, potential bottlenecks still exist at several basic levels in the metabolomics workflow. Therefore, we established a precise protocol initially for the G-Met analyses of human blood p...

Journal: :Anais da Academia Brasileira de Ciencias 2017
Tássia L A Dos Santos Raphael F Queiroz Alexandra C H F Sawaya Begoña Gimenez-Cassina Lopez Milena B P Soares Daniel P Bezerra Ana Carolina B C Rodrigues Vanderlúcia F DE Paula Ana Maria Waldschmidt

Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from Melipona mondury. In this study, we investigated the antioxidant, antibacterial, and antiproliferative activities of M. mondury geopropolis, and determined its chemical pro...

2015
An-Guo Wu Vincent Kam-Wai Wong Wu Zeng Liang Liu Betty Yuen-Kwan Law

With its traditional use in relieving insomnia and anxiety, our previous study has identified onjisaponin B from Radix Polygalae (RP), as a novel autophagic enhancer with potential neuroprotective effects. In current study, we have further identified a novel active fraction from RP, contains 17 major triterpenoid saponins including the onjisaponin B, by the combinational use of cell membrane ch...

2014
J. Klimes

The aim of this study was to develop a new, rapid and highly sensitive UHPLC method with UV detection for simultaneous determination of risperidone and four other related substances possibly present in tablets. The active substance, risperidone, is the most frequently used atypical antipsychotic drug for a treatment of schizophrenia, bipolar disease and behavioral disorders in young patients, u...

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