In multi-robot systems, efficient navigation is challenging as agents need to adjust their paths to account for potential collisions with other agents and static obstacles. In this paper, we present an online machine learning approach, -UCB, which improves global efficiency in the motions of multiple agents by building on ORCA, an existing multiagent navigation algorithm, and on UCB, a widely u...

Use of umbilical unrelated cord-blood (UCB) cells as an alternative source of hematopoietic cell transplantation has been widely used mainly for patients lacking an HLA-matched donor. UCB present many advantages over bone marrow or mobilized peripheral blood from volunteer donors, such as rapid availability, absence of risk for the donor, and decreased incidence of acute graft-versus-host disea...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Urothelial carcinoma of the bladder (UCB) is the second most common urological malignancy and ranking among the top ten malignancies in men and women, respectively (1). At initial presentation, the majority of patients have non muscle-invasive bladder cancer (NMIBC), but some patients have muscle-invasive UCB (MIBC) (...

Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment option for patients with acute myeloid leukemia. Recently, we reported a clinical-grade, cytokine-based culture method for the generation of NK cells from umbilical cord blood (UCB) CD34⁺ hematopoietic progenitor cells with high yield, purity and in vitro functionality. The present study was designed to ev...

OBJECTIVE A favorable incidence and severity of graft-vs-host disease is observed in patients transplanted with banked, unrelated, HLA-mismatched umbilical cord blood (UCB) grafts, while the incidence of malignant relapse remains low. CTLA-4 mediates negative T-cell signaling and may contribute to the development of allogeneic tolerance. In this study, we compared protein and mRNA expression of...

Using highly purified unconjugated [3H]bilirubin (UCB), we measured UCB binding to delipidated human serum albumin (HSA) and its uptake by basolateral rat liver plasma membrane vesicles, in both the absence and presence of an inside-positive membrane potential. Free UCB concentrations ([Bf]) were calculated from UCB-HSA affinity constants (K'f), determined by five cycles of ultrafiltration thro...

It is well established that high levels of unconjugated bilirubin (UCB) can be toxic to the central nervous system, and oxidative stress is emerging as a relevant event in the mechanisms of UCB encephalopathy. In contrast, the hydrophilic bile acid, ursodeoxycholic acid (UDCA), has been reported as a cytoprotective and antioxidant molecule. In this study, we investigated if exposure of rat neur...

F.-C. Lin, Center for Imaging the Earth’s Interior, Department of Physics, University of Colorado, 390 UCB, Boulder, CO, 80390-0390, USA. ([email protected]) M. P. Moschetti, Center for Imaging the Earth’s Interior, Department of Physics, University of Colorado, 390 UCB, Boulder, CO, 80390-0390, USA. ([email protected]) M. H. Ritzwoller, Center for Imaging the Earth’s Interior, D...

Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands University of Texas SW Medical Center, Dallas, Texas, USA Schoen Klinik, Hamburg, Germany Division of Arthritis/Rheumatic Diseases (OPO9), Oregon Health & Science University, Portland, Oregon, USA UCB Pharma, Brussels, Belgium UCB Pharma, Monheim am Rhein, Germany UCB Pharma, Raleigh, North Carolina, USA Swedi...

The authors previously demonstrated that unconjugated bilirubin (UCB) may inhibit the activities of various digestive proteases, including trypsin and chymotrypsin. The digestive proteases in the lower gut are important in the pathogenesis of inflammatory bowel diseases. The effects of UCB on the inflammation and levels of digestive proteases in feces of rats with colitis have not yet been reve...