UNLABELLED The aim of this study was to evaluate the diagnostic value of a new somatostatin analog, (68)Ga-labeled 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotide ((68)Ga-DOTA-TOC), for PET in patients with known or suspected neuroendocrine tumors. PET was compared with conventional scintigraphy and dedicated CT. METHODS Eighty-four patients (48 men, 3...

Comparative studies of the retention of various yttrium 90 radiocolloids and of noncolloidal yttrium 90 chloride were performed in rabbits with arthritis induced in one knee. Two colloids, the citrate and resin forms, showed a statistically significant difference in retention between inflamed and normal knees, isotope being retained better in the normal knee. Marked differences were found in th...

Transition metal perovskites have been studied for decades because of their unusual electronic and magnetic properties arising from narrow 3d bands and strong Coulomb correlations. The 3d1 perovskites are particularly interesting since despite the lack of multiplet effects similar materials have very different electronic properties: strontium and calcium vanadate are correlated metals with mass...

Previous work has shown the beneficial effect of yttrium implantation on the oxidation behaviour of chromium oxide forming alloys. Because of the limited applicabihty of Fe-Cr-Ni alloys in sulphur containing gases the effect of yttrium implantation on the aulphidation of Incoloy 800H was studied. In short time tests a significant improvement was observed upon implantation of about 10lh yttrium ...

UNLABELLED Gene therapy trials have traditionally used tumor and tissue biopsies for assessing the efficacy of gene transfer. Noninvasive imaging techniques offer a distinct advantage over tissue biopsies in that the magnitude and duration of gene transfer can be monitored repeatedly. Human somatostatin receptor subtype 2 (SSTR2) has been used for the nuclear imaging of gene transfer. To extend...

Background The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of luminal breast cancers, however SPECT and scintigraphy imaging with agonistic sstr2 probes has been sub-optimal. High affinity antagonists can access more binding sites on the cell surface, resulting in higher tumor uptake and improved sensitivity. We compared the tumor uptake and biodistribution of the antagon...