Type 1 diabetes (T1D) and latent autoimmune in adults (LADA) represent the most common types of are characterized by different age onset, degrees immune-mediated destruction pancreatic beta cells rates disease progression towards insulin dependence. Several immunotherapies aimed to counteract responses against preserve beta-cell function currently being investigated, particularly T1D. Prelimina...

Type 1 diabetes mellitus (T1D) is an autoimmune disease encompassing the T-cell-mediated destruction of pancreatic β cells and the production of autoantibodies against islet proteins. In humoral autoimmunity in T1D, the detection of islet autoantibodies and the examination of their associations with genetic factors and cellular autoimmunity constitute major areas in both basic research and clin...

Aims/Hypotheses. People with type 1 (T1D) or 2 diabetes (T2D) who also have complications can pronounced cognitive deficits. It remains unknown, however, whether and how multiple co-occur dysfunction, particularly in youth-onset diabetes. Methods. Using data from the SEARCH for Diabetes Youth Study cohort, a prospective longitudinal we examined clustering of their underlying clinical factors pe...

Type 1 diabetes (T1D) is the second most frequent autoimmune disease in childhood. The long-term micro- and macro-vascular complications of diabetes are associated with the leading causes of disability and even mortality in young adults. Understanding the T1D etiology will allow the design of preventive strategies to avoid or delay the T1D onset and to help to maintain control after developing....

Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of β cells [1]. Beside genetic factors, environmental factors such as viruses have been reported to be associated with T1D in human. These viruses include Rubella virus and cytomegalo virus [2,3], coxsackieviruses [4], mumps virus [5], Epstein-Barr virus [6,7], varicella zostar virus [8], rotavirus [9], H1N1 influenza v...

ABBREVIATIONS AACE = American Association of Clinical Endocrinologists ACE = American College of Endocrinology DKA = diabetic ketoacidosis EMA = European Medicines Agency FDA = U.S. Food and Drug Administration SGLT-2 = sodium glucosecotransporter 2 T1D = type 1 diabetes T2D = type 2 diabetes.

Background. Type 1 diabetes (T1D) and type 2 diabetes (T2D) have been linked to Helicobacter pylori infection, although results are conflicting. No previous study addressed a possible link between H. pylori infection and latent autoimmune diabetes in adults (LADA). In this study, a correlation among H. pylori infection and the risk of autoimmune diabetes in comparison with T2D was investigated....

Background and Aims: The adipokine fatty-acid binding protein 4 (FABP4) has been implicated in the pathogenesis of cardiometabolic disorders. Blocking action FABP4 through genetic or pharmacological means a preclinical setting analyzing effects genetically reduced expression humans is suggested to protect against obesity-related metabolic derangements atherosclerosis. As cardiovascular disease ...

Abstract Introduction The Post-traumatic Stress Disorder (PTSD) is a group of persistent psychological and physiological symptoms due to traumatic, severe, event. Only few studies focused on the effects Covid-19 psychosocial outcomes in children with Type 1 Diabetes (T1D) their parents. Aim study aim this was evaluate presence PTSD parents T1D during COVID-19 pandemic lockdown. Patients methods...

Type 1 diabetes mellitus (T1D), also known as insulin dependent diabetes mellitus, is a chronic immune mediated disease that is characterized by selective loss of insulin producing β cells of the pancreatic islets in genetically susceptible subjects . The majority (95%) of cases are attributable to an autoimmune-mediated destruction of β cells (type 1a) while a small minority (5%) of cases resu...