نتایج جستجو برای: twist die
تعداد نتایج: 136612 فیلتر نتایج به سال:
The 20.9 kDa protein encoded by TWIST1 gene is a highly conserved transcription factor that belongs to the family of basic helix-loop-helix (bHLH) proteins. In vertebrates, it is involved in embryonic development through the regulation of epithelial-mesenchymal transitions (EMT) during neural crest migration, also it regulates mesoderm determination, myogenesis, and morphogenesis (Hebrok et al....
BACKGROUND Squamous cell carcinoma of the head and neck (SCCHN) is the seventh most common cancer worldwide. Unfortunately, the survival of patients with SCCHN has not improved in the last 40 years, and thus new targets for therapy are needed. Recently, elevations in serum level of interleukin 6 (IL-6) and expression of Twist in tumor samples were found to be associated with poor clinical outco...
Although hundreds of evolutionarily conserved microRNAs have been discovered, the functions of most remain unknown. Here, we describe the embryonic spatiotemporal expression profile, transcriptional regulation, and loss-of-function phenotype of Drosophila miR-1 (DmiR-1). DmiR-1 RNA is highly expressed throughout the mesoderm of early embryos and subsequently in somatic, visceral, and pharyngeal...
this paper introduces an innovative partially destructive method, called “twist-off”, for the assessment of in situ concrete strength. in this method a 40mm diameter metal probe is bonded to a concrete surface by means of a high strength epoxy resin adhesive. to measure the concrete compressive strength, a torque is applied using an ordinary torque-meter and the maximum shear stress at failure ...
We consider the azimuthal angle dependence in the cross section of the hard leptoproduction of a photon on a nucleon target. We show that this dependence allows to define observables that isolate the twist-two and twist-three sectors in the deeply virtual Compton scattering amplitude. All twist-two and twist-three Compton form factors can be extracted from measurements of the charge odd part of...
Angiogenesis is a critical step in the growth and dissemination of malignant diseases, including pancreatic cancer. Twist has been shown to stimulate angiogenesis in the tumor site. However, whether Twist contributes to angiogenesis in pancreatic cancer remains unknown. In this paper, we found that the expression of Twist was significantly increased in human pancreatic cancer cell lines and pan...
Twist-three analysis of photon electroproduction off pion. Abstract We study twist-three effects in spin, charge, and azimuthal asymmetries in deeply virtual Compton scattering on a spin-zero target. Contributions which are power suppressed in 1/Q generate a new azimuthal angle dependence of the cross section which is not present in the leading twist results. On the other hand the leading twist...
Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we report a mechanism by which Twist recruits BRD4 to direct WNT5A expression in basal-like breast cancer (BLBC). Twist contains a "histone H4-mimic" GK-X-GK motif that is diacetylated by Tip60. The diacetylated Twist binds the second bromodomain of BRD4,...
Twist is required in Drosophila embryogenesis for mesodermal specification and cell-fate choice. We have examined the role of Twist and Notch during adult indirect flight muscle development. Reduction in levels of Twist leads to abnormal myogenesis. Notch reduction causes a similar mutant phenotype and reduces Twist levels. Conversely, persistent expression, in myoblasts, of activated Notch cau...
BACKGROUND Long-term peritoneal dialysis (PD) results in functional and structural alterations of the peritoneal membrane. Previous studies have suggested that high glucose (HG) could induce transdifferentiation of peritoneal mesothelial cells into myofibroblasts, but the molecular mechanisms of HG-induced epithelial-to-mesenchymal transition (EMT) of human peritoneal mesothelial cells (HPMCs) ...
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