In this article, we describe the mathematical framework of the computational model at the core of the tool The Virtual Brain (TVB), designed to simulate collective whole brain dynamics by virtualizing brain structure and function, allowing simultaneous outputs of a number of experimental modalities such as electro- and magnetoencephalography (EEG, MEG) and functional Magnetic Resonance Imaging ...

The TVB receptor for subgroup B, D, and E avian sarcoma and leukosis viruses (ASLVs) is a tumor necrosis factor receptor-related protein that is most closely related to the TRAIL receptors. Here we show that the major subgroup B viral interaction determinants of TVB are contained within a linear 15-amino-acid peptide derived from the N-terminal region of the receptor. Moreover, this peptide was...

The avian sarcoma and leukosis virus (ASLV) envelope glycoprotein (Env) is activated to trigger fusion by a two-step mechanism involving receptor-priming and low pH fusion activation. In order to identify regions of ASLV Env that can regulate this process, a genetic selection method was used to identify subgroup B (ASLV-B) virus-infected cells resistant to low pH-triggered fusion when incubated...

Therapies that target tumor metabolism represent a new horizon in anticancer therapies. In particular, cancer cells are dependent on the generation of lipids, which are essential for cell membrane synthesis, modification of proteins, and localization of many oncogenic signal transduction enzymes. Because fatty acids are the building blocks of these important lipids, fatty acid synthase (FASN) e...

The effects of seawater and slurry ice bleeding methods on the sensory, microbiological and chemical quality changes of cod fillets during chilled storage were examined in this study. The results from sensory evaluation showed that slurry ice bleeding method prolonged the shelf life of cod fillets up to 13-14 days compared to 10-11 days for fish bled in seawater. Slurry ice bleeding method also...

We consider a family of high-order, weighted essentially non-oscillatory central schemes (CWENO) for approximating solutions of one-dimensional hyperbolic systems of conservation laws. We are interested in the behavior of the total variation (TV) of the approximate solution obtained with these methods. Our numerical results suggest that even though CWENO methods are not total variation diminish...

Continuous chromatographic separator techniques have allowed the extraction of more simple sugars from molasses (MOL). The resultant byproduct, concentrated separator byproduct (CSB), has reduced readily fermentable carbohydrates but elevated CP and mineral content. The feed value of CSB was compared to that of MOL in two separate trials. In Trial 1, a chopped forage mixture containing 8 4 O/O ...

We investigated the effects of tea polyphenol treatments on quality and microbiota crisp grass carp fillets during cold storage at 4 °C. Changes in total viable count (TVC) volatile base nitrogen (TVB-N) were measured. The was analyzed using high-throughput sequencing technique. results indicated that inhibited bacterial growth reduced TVB-N values fish fillets, subsequently extended their shel...