Keratin polypeptides 8 and 18 (K8/18) are intermediate filament (IF) proteins that are expressed in glandular epithelia. Although the mechanism of keratin turnover is poorly understood, caspase-mediated degradation of type I keratins occurs during apoptosis and the proteasome pathway has been indirectly implicated in keratin turnover based on colocalization of keratin-ubiquitin antibody stainin...

MAGE-A proteins are testis-specific E3 ubiquitin ligase components whose expression is upregulated in many cancers. MAGE-A3 and -A6 act as oncogenes and recent work now shows that they degrade the central metabolic regulator AMPK, providing a novel mechanism for rewiring cancer metabolism.

The very low abundance of mitochondrial DNA (mtDNA) mutations in nearly all mammalian tissues even in old age has led most mitochondriologists to reject the idea that such mutations might have a causal role in aging, despite (1) the strong circumstantial (e. g., interspecies) evidence that they do have such a role, (2) the promulgation since 1998 of two detailed mechanisms whereby low levels of...

The very low abundance of mitochondrial DNA (mtDNA) mutations in nearly all mammalian tissues even in old age has led most mitochondriologists to reject the idea that such mutations might have a causal role in aging, despite the strong circumstantial (e.g. interspecies) evidence that they do have such a role, the promulgation since 1998 of two detailed mechanisms whereby low levels of mtDNA mut...

Kykyri, Virpi-Liisa Helping Clients to Help Themselves. A Discursive Perspective to Process Consulting Practices in Multi-party Settings Jyväskylä, University of Jyväskylä, 2008, 76 p. (Jyväskylä Studies in Education, Psychology and Social Research ISSN 0075-4625; 330) ISBN 978-951-39-3082-0 (PDF), 978-951-39-3071-4 (nid.) Finnish Summary Diss. This study approaches process consulting work as c...

We report on the status of emittance tuning techniques at the CESR Test Accelerator (CesrTA). The CesrTA experimental program requires that we operate in a variety of machine lattices, each with the smallest possible emittance. We utilize high-bandwidth BPM electronics for fast, precision measurements of orbit, betatron phase, transverse coupling, and dispersion. Analysis of the data and implem...

The surveillance game [Fomin et al., 2012] models the problem of web-page prefetching as a pursuit evasion game played on a graph. This two-player game is played turn-by-turn. The first player, called the observer, can mark a fixed amount of vertices at each turn. The second one controls a surfer that stands at vertices of the graph and can slide along edges. The surfer starts at some initially...