Glioblastoma multiforme, a neoplasm with variable histological and biological features, is characterized by diverse imaging features, including highly heterogeneous enhancement. This reflects variable disruption of the blood brain barrier and inherent differences in the vascularity of the tumor. Experience in treating malignant glioma with antiangiogenic drugs is growing, and the most commonly ...

For a biologically validated mathematical model for tumor antiangiogenesis developed by Hahnfeldt et al [3] the scheduling of angiogenic inhibitors is analyzed as an optimal control problem. In the objective a weighted balance between tumor reduction and the total amount of angiogenic inhibitors given is considered. Bifurcations of optimal solutions are illustrated numerically. AMS Subject Clas...

Metastatic prostate cancer is the second leading cause of cancer related death. While androgen ablation is an effective initial modality, progression of disease is eventually occurred in majority patients. The benefit of chemotherapy in overall survival is still unclear. Angiogenesis plays a pivotal role for the growth, invasion, and metastasis of prostate cancer. Therefore, antiangiogenesis is...

Systemic chemotherapy has become the cornerstone of therapy for retinoblastoma. The advent of novel chemotherapeutic and antiangiogenesis agents together with new routes of drug administration including periocular, intravitreal and intra-ophthalmic artery injection will hopefully revolutionize the management of this sight-threatening and potentially fatal infantile ocular neoplasm.

The chick embryo chorioallantoic membrane (CAM) is commonly used as an experimental in vivo assay to study both angiogenesis and antiangiogenesis in response to tissues, cells or soluble factors. This article summarizes literature data about the use of the CAM in the study of tumor angiogenesis and particularly our experimental data concerning the study of angiogenesis in multiple myeloma and i...