aim : to create an orthotopic hepatoma model with local metastasis monitored with ultrasound could be created as a platform for testing new treatments.   background : hepatoma accounts for 25% of liver tumors in children with poor overall survival. intraabdominal metastasis are present in 35% of patients at time of diagnosis.  we hypothesized that an orthotopic tumor model with local metastasis...

Objective- Breast cancer is one of the most serious problems in oncology. Alkaloids pyrrolizidine are widely found in nature and exhibited versatile biological activities. The aim of the present study was to assess anti-tumor activity of methyl 1,3-dioxo-1,1',2',3,5',6',7',7a'-octahydrospiro[indene-2,3'-pyrrolizidine]-2'-carboxylate (6) on 7,12 dimethylbenz(a) anthracene (DMBA)-induced mammary ...

OBJECTIVE Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS Our sample consisted of consecutive patients evaluated in the period from 1989 to 2009 in an Onco-Hematology Service. Clinical, histological and volumetric data were collected from ...

introduction as a tumor grows, the demand for oxygen and nutrients increases and it grows further if acquires the ability to induce angiogenesis. in this study, we aimed to present a two-dimensional continuous mathematical model for avascular tumor growth, coupled with a discrete model of angiogenesis. materials and methods in the avascular growth model, tumor is considered as a single mass, wh...

introduction: daphne species has both pharmaceutical applications and anti tumor activity. it has been shown that the extract of daphne mucronata is effective in decreasing the size of breast adenocarcinoma in rats. we investigated the mechanism of action and the effects of the extract on tnf-a and tnf-a receptors on cultured human monocytes. material and methods: the breast tumors were induced...

background: the aim of this study was to detect prognostic factors in recurrent breast cancer metastasis. materials and methods: th is retrospective cohort study employed data from 996 breast cancer patients of isfahan seyed-o-shohada research center from 1998 to 2010. stratifi ed cox proportional hazards model, marginal approach, was used to evaluate the prognostic value of estrogen receptor, ...

Background and Objectives: RCC is one of the most common genitourinary cancers. Accurate prediction of prognosis would be valuable for adjuvant trial design, counseling and effectively scheduling follow up visits. P53 is a tumor suppressor gene that expresses a protein that involved in both cell-cycle ar...

background: to explore a possible rela!onship among blood groups and the prognosis of breast cancer, this case- control study was carried out in arak city, arak province, iran. materials and methods: one hundred and thirty four pa!ents with breast cancer were inves!gated. abo blood groups were obtained from medical records. mul!variate analyses were performed, including size of tumor, axillary ...