Mycobacterium tuberculosis infection is accompanied by acute and chronic inflammatory infiltrates associated with necrotizing granulomas in lung tissue. The cellular infiltrate is characterized by inflammatory cells which include neutrophils, lymphocytes, and macrophages. In animal and in vitro models of mycobacterial infection, cytokines including tumor necrosis factor-alpha (TNF-alpha), inter...

background: inflammatory response following surgical trauma has long been a matter of study. results, however, have been varied. we sought to assess changes in the levels of proinflammatory and anti-inflammatory cytokines in patients undergoing laparoscopic and open cholecystectomy and their impact on the clinical outcome of patients concerning the postoperative pain score. methods: the study i...

The mechanism of action of some antitumor agents (3-5) has been investigated in recent years by studying their effects in combination with other agents that may be antagonistic or synergistic. Previous work1 in this laboratory showed that the tumor-necrotizing action of the bacterial polysaccharide from Serratia marcescens and of some other tumor-necrotizing agents was reduced by pre-administra...

The aim of the present study was to determine the level of Tumor necrosis factor-alpha in aqueous humor and serum of patients with pseudo exfoliation syndrome. The materials and methods in this study, we measured the level of Tumor necrosis factor-alpha, in aqueous and serum of patients with pseudo exfoliation syndrome and compared the findings with healthy controls. The Results are Regarding A...

inflammatory bowel disease (ibd) is a chronic disease of unknown etiology, in which genetic factors, seem to play an important role in the disease predisposition and course. assessment of tumor necrosis factor (tnf-α) gene polymorphisms in many populations showed a possible association with ibd. considering the genetic variety in different ethnic groups, the aim of the present study was to inve...

Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message turnover, message splicing, translation, and protein cleavage from the cell surface all being independently regulated. This study examined both cell line...