background: infertility is a problem concerning 10-15% of the individuals in the fertile period. this study investigated effects of proinflammatory factors as well as lipid hydroperoxides (lpo) levels upon in vitro fertilization (ivf) success. materials and methods: in this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (group-1), 26 infertile women before...

pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. alleles of the interleukin-l-beta (il-lβ) and tumor necrosis factor alpha (tnf-α) genes are associated with pr-eeclampsia in several studies in different popul...

Aim. To estimate the concentration of tumor necrosis factor-alpha (TNF-α), interleukin-6 (interleukin, IL-6), vascular endothelial growth factor (VEGF) in blood serum and to analyze polymorphism TNF-α cytokine genes region 308G / A (rs1800629), IL-6 174G C (rs1800795) VEGFA 634G (rs2010963) patients with chronic diffuse liver diseases (CDLD) living Perm region. Materials methods. In 193 CDLD 90...

INTRODUCTION Axonal degeneration and retinal ganglion cell apoptosis in glaucoma is associated with tumor necrosis factor alpha (TNF-α), which is an important pro-inflammatory cytokine. The aim of this study was to determine the association between the risk of open angle glaucoma (OAG) in the Egyptian population and tumor necrosis factor alpha (TNF-α) gene polymorphisms. METHODS Sixty OAG pat...

Complementary DNA clones encoding two distinct tumor necrosis factor receptors were isolated from a mouse macrophage cDNA library. The cDNA for murine tumor necrosis factor receptor type 1 (mTNF-R1) predicts a mature polypeptide of 425 amino acids that is 64% identical to its human counterpart, whereas the cDNA of murine tumor necrosis factor receptor type 2 (mTNF-R2) predicts a mature protein ...

In cigarette smoke-induced and inflammation-associated lung cancer development, cigarette smoke extract (CSE) activates tumor necrosis factor-alpha (TNF-α) secretion from macrophages. TNF-α converting enzyme (TACE), also known as α-Secretase or ADAM17 (A Disintegrin and Metalloprotease), is a member of the ADAM family of metalloproteases. TACE mediated ectodomain shedding leads to the conversio...

BACKGROUND Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet's disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activ...

To investigate the association of plasma levels of tumor necrosis factor-alpha (TNF-α) in patients with primary open angle glaucoma (POAG) patients as compared to non-glaucomatous controls. TNF-α concentrations were measured using sandwiched enzyme-linked immunosorbent assay (ELISA) in plasma samples from 39 POAG patients and 36 controls. The assay was performed in duplicate on an automated Che...

We present a patient who had rheumatoid meningitis while on infliximab, a tumor necrosis factor alpha (TNF-α) inhibitor, which initially presented as transient ischemic attacks. Although our patient had been stable on infliximab for several years, her neurologic symptoms improved when her infliximab was held due to active infection and then recurred after reinitiation of therapy. Rheumatoid men...