vascular adhesion protein-1 (vap-1) is an endothelial cell surface-expressed oxidase involved in leukocyte traffic. the adhesive function, and therefore leukocyte infiltration to different tissues, can be blocked by anti-vap-1 antibodies as well as small molecule vap-1 inhibitors. several papers have been published on the effect of vap-1 blockade on both leukocyte accumulation into tumors and n...

Abstract In several cancers, including the aggressive sarcoma, rhabdomyosarcoma (RMS), tumor-associated myeloid cells (TAMCs) are largest immune populations and correlated with poor survival outcomes. TAMCs a mixed ‘plastic’ population that can sense changes in their environment, intra-tumoral ECM stiffness, change functioning accordingly. Despite clinical influences these have detrimental effe...

Theranostics The study in article number 2102816 by Hui Mao and co-workers reports systemic targeted delivery of sub-5 nm theranostic iron oxide nanoparticles carrying the anti-cancer topoisomerase I inhibitor, SN38, to intracranial tumors glioblastoma via enhanced permeability retention effect tumor integrin targeting, leading improved efficacy growth inhibition.

Abstract Glioblastoma is the most aggressive primary brain tumor and adults poorly immunogenic. Treatment options for recurrent glioblastoma after standard of care chemoradiation are limited Several immunotherapeutic strategies including peptide vaccination immune checkpoint inhibition have so far failed to improve survival except from potentially regorafenib, no other agent has demonstrated su...

The Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase signaling pathway is involved in cellular responses relevant to tumorigenesis, including cell proliferation, invasion, survival, and angiogenesis. 2-[4-[(1E)-1-(Hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879) is a novel, potent, and selective B-Raf inhibit...

background: sclareol is a phytochemical used in people's diet in southeast asia. objective: to investigate the immunotherapeutic effectiveness of sclareol against breast cancer by direct intraperitoneal injection. methods: sclareol was isolated and purified from salvia sclarea. effect of sclareol on cell growth inhibition was evaluated by mtt assay. intraperitoneally injected sclareol effe...

Neuroblastomas are the most common extracranial solid tumors in children and have a unique feature of neuronal differentiation. Peroxisome proliferator-activated receptor (PPAR)-γ is reported to neuroprotective effects addition having antitumor various cancers. Thus, we aimed clarify role PPAR-γ agonist antagonist malignant neuroblastomas, which also possess features. In MYCN-amplified neurobla...

Abstract Glioblastoma (GBM) is the most aggressive adult brain tumor, with a median survival of 15 months despite current treatments. We recently established that epigenetic regulator Disruptor Telomeric Silencing-1-Like (DOT1L) was essential for growth tumor stem cells (BTSCs), which are thought to underlie GBM initiation and treatment resistance. Given previously recognized importance DOT1L h...

PURPOSE The epidermal growth factor receptor (ERBB1) and related family member HER-2/neu (ERBB2) are often overexpressed in aggressive breast cancers and their overexpression is correlated with poor prognosis. Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. Our studies were designed...