objectives: epithelial-mesenchymal transition (emt) is a fundamental stage in cancer metastasis and the presence of vascular invasion is a strong indication of the spread of the malignant tumor cells. regulation of the emt is a complex process in which several different transcription factors are involved. eomesodermin (eomes) as a member of the t-box gene family is an important component in the...

background of the study: colorectal cancer (crc) which is the third most diagnosed cancer throughout the world is steadily rising in the asian countries with the incidence rates mimicking the western counterparts. the pre-neoplastic nature of the transitional mucosa (tm) adjoining crc lacks conclusive evidence so far. pertaining to this, the study of the mucus layer, the functional component of...

We report the first known case of an adrenal teratoma containing a Wilms tumor component, in 12-month-old girl with Trisomy 21. Despite teratomas being relatively uncommon, this particular instance raises interesting questions regarding origin, given coexistence both and tumor. Two main theories development have been hypothesized, one which suggests that may develop from primary other proposing...

This study histopathologically and immunohistochemically investigated a spontaneously occurring single mass subcutaneously located in the left lower abdomen of a female BALB/cAJcl-nu/+ mouse at 10 weeks of age. The mass was about 20 × 15 × 10 mm in size after formalin fixation; nevertheless, it was not detected by clinical observations at 9 weeks of age. H&E staining revealed the tumor origin w...

purpose: to present a case of orbital granular cell tumor, a rare orbital tumor. case report: a 55-year-old woman presented with binocular diplopia and right ocular displacement. the problem had initiated 3 years ago. a firm nontender mass at the region of the right lower lid was visible. orbital ct-scan disclosed a well-defined mass in the inferior right orbit with involvement of the inferior ...

The undifferentiated embryonal sarcoma of the liver is a rare tumor with poor prognosis, improved outcomes being reported more recently multimodality treatments. We report case 6-year-old girl an incidentally diagnosed and histologically proven localized liver. divergence between solid appearance at US cystic-like on CT/MRI, which has been attributed to presence myxoid component frequently desc...

results there was no statistical difference between the 2 groups with respect to the recurrence rate (p > 0.05). although the recurrence interval was longer for the metformin group, this increase was not statistical significant (p > 0.05). furthermore, tumor recurrence had no correlation with sex or the grade of the tumors. conclusions according to our findings, it seems that metformin has no c...

primary pancreatic leiomyosarcomas are rare malignant neoplasms with an aggressive course and a large size. a 56-year-old woman presented with an 8-year history of abdominal pain. multislice computed tomography revealed a large heterogeneous mass with necrotic, calcified and macroscopic fatty areas. the tumor was excised. histopathological evaluation revealed leiomyosarcoma of the pancreas. if ...