Lymphocytes separated from surgically resected tumor tissue, imiiivolved lung tissue, and peripheral blood of lung cancer patients were investigated for cytotoxic potential and analyzed for their phenotypes at the time of surgery and after having been propagated for 4 to 5 wk in the presence of interleukin-2. Most of the tumor lymphocyte infiltrates examined were shown to have a shift in favor ...

The secret to tumor growth and survival is proliferation. Therefore, plan formulate a required therapy process, the study of propagation rate very important. objective immune system protect against disease or other potentially harmful foreign bodies, set processes mechanisms within body. In regulating tumor, different cells our perform their assigned function. Natural Killer cells, Dendritic CD...

NK assay using flow cytometry. J Immunol Methods 1986; 86: 7-15. 7 Abo T, Balch C M. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol 1981; 127: 1024-9. 8 Lanier L L, Le A M, Phillips J H, Warner N L, Babcock G F. Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. J Immunol ...

Abstract Inhibitory killer cell immunoglobulin–like receptors (iKIR) tolerize natural cells and some T upon detecting classical HLA class I molecules. In this issue, Bhatt colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR member, KIR3DL3. These data establish new inhibitory checkpoint pathway that may protect HHLA2+ tumor from immune attack. See artic...

Abstract The progression and metastatic capacity of solid tumors are strongly influenced by immune cells in the tumor microenvironment. In non–small cell lung cancer (NSCLC), accumulation anti-inflammatory tumor-associated macrophages (TAM) is associated with worse clinical outcome resistance to therapy. Here we investigated landscape NSCLC presence protumoral TAMs expressing macrophage recepto...

A unique class of IFN-producing killer dendritic cells (IKDC) resembling natural killer cells has been defined that can recognize and lyse tumor cells through a tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanism. IKDC may mediate the host-dependent antitumor activity of Gleevec/STI571 and other therapeutics that can inhibit the c-kit tyrosine kinase. IKDC represent an i...

We studied the effect of protein-bound polysaccharide PSK on the activation of the human natural killer cell line NKL. We observed an increased natural killer cytotoxic activity against different tumor cells (K562, Daudi, and U937) when a standard 2- to 3-h 51chromium release assay was performed. The results parallel those obtained after treatment of the NKL cell line with interleukin-2. The hi...