نتایج جستجو برای: ttg

تعداد نتایج: 923  

Journal: :The Journal of biological chemistry 2000
J Wu S L Liu J L Zhu P A Norton S Nojiri J B Hoek M A Zern

The mechanisms by which ethanol inhibits hepatocyte proliferation have been a source of some considerable investigation. Our studies have suggested a possible role for tissue transglutaminase (tTG) in this process. Others have shown that tTG has two distinctly different functions: it catalyzes protein cross-linking, which can lead to apoptosis and enhancement of extracellular matrix stability, ...

2003
I R Korponay-Szabó I Dahlbom K Laurila S Koskinen N Woolley J Partanen J B Kovács M Mäki T Hansson

Background: IgA serum autoantibodies against tissue transglutaminase (tTG) have an established diagnostic value in coeliac disease, and high efficacy tests are widely available for their detection. However, serological evaluation of IgA deficient subjects is still difficult. Aims: To evaluate the diagnostic potential of IgG class anti-tTG autoantibodies measured quantitatively using an enzyme l...

Introduction: Celiac disease can be associated with other diseases, including neurological disorders. In this study, the relationship between celiac disease and refractory epilepsy was evaluated in patients who were referred to Imam Khomeini Hospital in Urmia. Methods: In this cross-sectional study, patients with refractory epilepsy who were referred to the neurology clinic of Imam Khomeini Ho...

2014
Hideyuki Nakazawa Hideki Makishima Toshiro Ito Hiroyoshi Ota Kayoko Momose Nodoka Sekiguchi Kaname Yoshizawa Taiji Akamatsu Fumihiro Ishida

The prevalence of celiac disease (CD) among Japanese population has been unknown, whereas it has been increasingly recognized in the US and in the European countries. The aim of the present study is to identify possible cases with CD among Japanese population and clarify the relevance of screening for the disease. We conducted a serologic screening for the disease among 710 Japanese patients an...

Journal: :Clinical chemistry 2006
Antonio Carroccio Lidia Di Prima Giuseppe Pirrone Calogero Scalici Ada M Florena Maurizio Gasparin Giuseppe Tolazzi Antonino Gucciardi Carmelo Sciumè Giuseppe Iacono

BACKGROUND We measured anti-transglutaminase (anti-tTG) antibody in the culture medium of intestinal biopsy specimens from patients with suspected celiac disease (CD) and evaluated the relationship between antibody production and severity of intestinal mucosal damage. METHODS We performed diagnostic testing for CD on 273 consecutive patients. In addition to routine histologic evaluation of du...

Journal: :Journal of pediatric gastroenterology and nutrition 2012
Maria G Alessio Elio Tonutti Ignazio Brusca Antonella Radice Lisa Licini Aurelio Sonzogni Ada Florena Eugenio Schiaffino Wally Marus Sandro Sulfaro Danilo Villalta

OBJECTIVES Positivity of both immunoglobulin A anti-tissue transglutaminase (TTG) and anti-endomysium antibodies (EMA) has a positive predictive value of nearly 100% for celiac disease (CD). The objective of the present study was to evaluate whether patients of any age, with high pretest probability of CD and high titre of anti-TTG and EMA positivity, have a high probability of intestinal damag...

Journal: :Journal of immunology 2005
Daniele Sblattero Francesco Maurano Giuseppe Mazzarella Mauro Rossi Salvatore Auricchio Fiorella Florian Fabiana Ziberna Alberto Tommasini Tarcisio Not Alessandro Ventura Andrew Bradbury Roberto Marzari Riccardo Troncone

Type 1 diabetes mellitus is an autoimmune disorder characterized by destruction of insulin-producing pancreatic beta cells by T lymphocytes. In nonobese diabetic (NOD) mice, a role has been hypothesized for dietary gluten proteins in the onset of diabetes, and because gluten dependence is the major feature of celiac disease, together with production of Abs to the autoantigen tissue transglutami...

Journal: :The Journal of biological chemistry 1998
T S Lai T F Slaughter K A Peoples J M Hettasch C S Greenberg

Tissue transglutaminase (tTG) catalyzes a Ca(2+)-dependent transglutaminase (TGase) activity that stabilizes tissues and a GTP hydrolysis activity that regulates cell receptor signaling. The purpose of this study was to examine the true substrates for nucleotide hydrolysis and the effects of these substrates on modulating the dual enzymatic activities of tTG. We found that Mg-GTP and Mg-ATP are...

Journal: :Geology 2021

Abstract The oldest geological materials on Earth are Hadean (>4 Ga) detrital zircon grains. Their chemistry and apparently low Ti-in-zircon temperatures (?700 °C) considered to be inconsistent with crystallization in a magma of the tonalite-trondhjemite-granodiorite (TTG) suite, although these dominant Archean (4.0–2.5 silicic rocks. Using new data set trace element contents zircons fro...

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