IFE expectancy and the degree of invalidism have been considered a function of the type of cardiac malformation in patients with congenital heart disease. When the abnormality involves a large communication between the ventricles or great vessels, however, the pulmonary vascular bed plays an important role in governing prognosis. The following group of congenital malformations are involved in t...

The value of two dimensional echocardiography in identifying communications between the ascending aorta and pulmonary trunk or individual pulmonary arteries was assessed in 24 children, all of whom had either angiocardiographic and surgical or angiocardiographic confirmation alone. Fourteen cases had truncus arteriosus, four aortopulmonary window, four anomalous origin of the left pulmonary art...

VENOUS angiocardiographic demnonstration of a single arterial vessel leaving the heart and supplying both systenmic and pulmonary circulations, suggests the diagnosis of persistent truncus arteriosus. Such was the initial impression in the ease of a dyspneie, cyanotic, newborn male infant without a cardiac murmur. The electrocardiogram showed a normal sinus rhythm. The mean manifest electrical ...

Among certain patients with cardiovascular malformations, a common phenomenon is a ventricular septal defect and absence of anatomic origin of the pulmonary arterial supply from the heart. In this situation, true pulmonary arteries may be present or absent. In the latter case, the pulmonary arterial supply comes through bronchial arteries. When true pulmonary arteries are present, the left and ...

Background: VACTERL association is usually a sporadic disorder, the possible etiologies of which have been proposed as familial as well as multiple genetic and environmental factors. VACTERL association usually consists of at least three of the core features of vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, and limb abnormalities. Vertebral anomali...

were present in the ventricular myocytes from hearts at day 11 of incubation. However, day 11 hearts with persistent truncus arteriosus showed a twofold reduction in the peak magnitude of ICa.L at a test potential of + 10 mV without a concomitant reduction in the number of L channels detected by 1,4-dihydropyridine antagonist [(+)[3H]PN200-110] and agonist (Bay K 8644) receptor binding. The res...